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- W4299362009 abstract "Protease inhibitors, a new class of anti-HIV medications, inhibit the actions of HIV protease, a compound necessary for proper HIV replication. When the actions of this protease are blocked, defective copies of HIV are made or new virus is not produced. These new medications are less damaging to cells than nucleoside analogues (such as AZT and 3TC) because their activities are targeted and more specific. Research has shown that protease inhibitors reduce the amount of measurable HIV virus in the blood and, in some cases, increase T4 cell counts. For best results, these drugs will probably need to be taken in combination with other anti-HIV medications, such as nucleoside analogues or other protease inhibitors, because the beneficial effects of single drug therapy wears off quickly when drug resistance develops. Resistance evolves due to the frequent mutations occurring during HIV viral replication. These mutations can produce a version of HIV protease that is not blocked by the protease inhibitor. However, combination therapy involving the use of two or more protease inhibitors may slow the development of resistance." @default.
- W4299362009 created "2022-10-02" @default.
- W4299362009 date "1995-08-01" @default.
- W4299362009 modified "2023-09-29" @default.
- W4299362009 title "Protease inhibitors." @default.
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