Matches in SemOpenAlex for { <https://semopenalex.org/work/W4299458416> ?p ?o ?g. }
- W4299458416 endingPage "19895" @default.
- W4299458416 startingPage "19884" @default.
- W4299458416 abstract "Abnormal metabolic symbiosis is a typical characteristic that differentiates the tumor regions from healthy tissues and meanwhile maintains tumor survival. It is of great potential to disrupt intratumoral metabolic symbiosis in tumor therapy. Herein, we report a specific tumor therapy strategy through inducing acidosis to disrupt intratumoral metabolic symbiosis for tumor elimination, which is based on carbonic anhydrase inhibitor (CAI)-modified ferrous sulfide nanoparticles (FeS-PEG-CAI NPs). The FeS-PEG-CAI NPs show the acid-responsive degradation capacity to release functional components, including CAI, Fe2+, and H2S, while remaining quite stable under normal physiological conditions. The generated CAI and H2S gas can not only disrupt the intracellular metabolic symbiosis to induce acidosis but also provide suitable circumstances for Fe2+-mediated Fenton reaction, producing abundant toxic hydroxyl radicals. Meanwhile, these NPs also show the dual-mode imaging capacity with photoacoustic and magnetic resonance imaging, which can dynamically monitor tumor location in the process of synergistic chemodynamic/photothermal/gas therapy. Overall, the developed FeS-PEG-CAI NPs exert their role of disrupting intratumoral metabolic symbiosis and other synergistic effects, which further enrich tumor treatment strategies." @default.
- W4299458416 created "2022-10-02" @default.
- W4299458416 creator A5010995624 @default.
- W4299458416 creator A5014222930 @default.
- W4299458416 creator A5023824810 @default.
- W4299458416 creator A5046393276 @default.
- W4299458416 creator A5047141692 @default.
- W4299458416 creator A5053703803 @default.
- W4299458416 creator A5067221645 @default.
- W4299458416 creator A5068161836 @default.
- W4299458416 creator A5087247583 @default.
- W4299458416 creator A5090911302 @default.
- W4299458416 date "2022-10-02" @default.
- W4299458416 modified "2023-10-17" @default.
- W4299458416 title "Biodegradable Ferrous Sulfide-Based Nanocomposites for Tumor Theranostics through Specific Intratumoral Acidosis-Induced Metabolic Symbiosis Disruption" @default.
- W4299458416 cites W1636028712 @default.
- W4299458416 cites W1939035431 @default.
- W4299458416 cites W1990391394 @default.
- W4299458416 cites W1998166655 @default.
- W4299458416 cites W2010967562 @default.
- W4299458416 cites W2014515422 @default.
- W4299458416 cites W2033733148 @default.
- W4299458416 cites W2066520032 @default.
- W4299458416 cites W2094304123 @default.
- W4299458416 cites W2118817262 @default.
- W4299458416 cites W2147035772 @default.
- W4299458416 cites W2258066491 @default.
- W4299458416 cites W2497807614 @default.
- W4299458416 cites W2586265133 @default.
- W4299458416 cites W2610893008 @default.
- W4299458416 cites W2753698552 @default.
- W4299458416 cites W2765303057 @default.
- W4299458416 cites W2790858728 @default.
- W4299458416 cites W2797246868 @default.
- W4299458416 cites W2883440571 @default.
- W4299458416 cites W2887621482 @default.
- W4299458416 cites W2901821976 @default.
- W4299458416 cites W2911926113 @default.
- W4299458416 cites W2938272498 @default.
- W4299458416 cites W2939712722 @default.
- W4299458416 cites W2945184742 @default.
- W4299458416 cites W2947512353 @default.
- W4299458416 cites W2984799663 @default.
- W4299458416 cites W2990440610 @default.
- W4299458416 cites W3000852122 @default.
- W4299458416 cites W3008165209 @default.
- W4299458416 cites W3008370485 @default.
- W4299458416 cites W3024372238 @default.
- W4299458416 cites W3048510814 @default.
- W4299458416 cites W3093381368 @default.
- W4299458416 cites W3097560427 @default.
- W4299458416 cites W3125590654 @default.
- W4299458416 cites W3125944921 @default.
- W4299458416 cites W3146001933 @default.
- W4299458416 cites W3153968372 @default.
- W4299458416 cites W3154940127 @default.
- W4299458416 cites W3170263392 @default.
- W4299458416 cites W3196902013 @default.
- W4299458416 cites W3201772330 @default.
- W4299458416 cites W3211895768 @default.
- W4299458416 cites W3216225142 @default.
- W4299458416 cites W4200528729 @default.
- W4299458416 doi "https://doi.org/10.1021/jacs.2c07669" @default.
- W4299458416 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36183257" @default.
- W4299458416 hasPublicationYear "2022" @default.
- W4299458416 type Work @default.
- W4299458416 citedByCount "21" @default.
- W4299458416 countsByYear W42994584162023 @default.
- W4299458416 crossrefType "journal-article" @default.
- W4299458416 hasAuthorship W4299458416A5010995624 @default.
- W4299458416 hasAuthorship W4299458416A5014222930 @default.
- W4299458416 hasAuthorship W4299458416A5023824810 @default.
- W4299458416 hasAuthorship W4299458416A5046393276 @default.
- W4299458416 hasAuthorship W4299458416A5047141692 @default.
- W4299458416 hasAuthorship W4299458416A5053703803 @default.
- W4299458416 hasAuthorship W4299458416A5067221645 @default.
- W4299458416 hasAuthorship W4299458416A5068161836 @default.
- W4299458416 hasAuthorship W4299458416A5087247583 @default.
- W4299458416 hasAuthorship W4299458416A5090911302 @default.
- W4299458416 hasConcept C12554922 @default.
- W4299458416 hasConcept C178790620 @default.
- W4299458416 hasConcept C185592680 @default.
- W4299458416 hasConcept C2775832776 @default.
- W4299458416 hasConcept C502942594 @default.
- W4299458416 hasConcept C55493867 @default.
- W4299458416 hasConcept C86803240 @default.
- W4299458416 hasConceptScore W4299458416C12554922 @default.
- W4299458416 hasConceptScore W4299458416C178790620 @default.
- W4299458416 hasConceptScore W4299458416C185592680 @default.
- W4299458416 hasConceptScore W4299458416C2775832776 @default.
- W4299458416 hasConceptScore W4299458416C502942594 @default.
- W4299458416 hasConceptScore W4299458416C55493867 @default.
- W4299458416 hasConceptScore W4299458416C86803240 @default.
- W4299458416 hasFunder F4320321001 @default.
- W4299458416 hasFunder F4320321540 @default.
- W4299458416 hasFunder F4320322919 @default.
- W4299458416 hasIssue "43" @default.
- W4299458416 hasLocation W42994584161 @default.