FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4299458417> ?p ?o ?g. }

• W4299458417 endingPage "103139" @default.
• W4299458417 startingPage "103139" @default.
• W4299458417 abstract "In 2020, the estimated number of new leukemia cases was higher than 30,000 in girls between 0 and 19 years old. Due to cancer treatment, some of these patients may lose both endocrine and reproductive functions. Transplantation of cryopreserved ovarian tissue is not advised after cancer remission because it has a high risk of reintroducing malignant cells in the patient, potentially leading to leukemia recurrence. To safely transplant the ovarian tissue from these patients and restore their fertility, our goal was to develop a photodynamic therapy (PDT) strategy to eliminate leukemia ex vivo. To this end, we designed, optimized, and characterized OR141-loaded niosomes (ORN) to develop the most effective formulation for ex vivo purging ovarian fragments from chronic myelogenous leukemia cells. After establishing the best ORN formulation, the PDT efficiency of optimized ORN was determined for human ovarian stromal cells and acute myeloid leukemia cell line (HL60). Blank niosomes treatment on ovarian stromal cells causes no significant toxicity, showing that the composition of the nanoparticle is not toxic. On the other hand, the in vitro studies showed that while ovarian stromal cells were still viable (82.04 ± 2.79%) after the treatment by 0.5 µM ORN, the same treatment yielded 95.43 ± 3.89% toxicity and cell death in the cancer cells. In conclusion, our results showed that our novel PDT procedure could be a promising strategy to destroy leukemia cells in ovarian tissue fragments allowing safe transplantation in cancer survivors." @default.
• W4299458417 created "2022-10-02" @default.
• W4299458417 creator A5036421912 @default.
• W4299458417 creator A5054901204 @default.
• W4299458417 creator A5056903468 @default.
• W4299458417 creator A5059376263 @default.
• W4299458417 creator A5063029358 @default.
• W4299458417 creator A5067067491 @default.
• W4299458417 date "2022-12-01" @default.
• W4299458417 modified "2023-10-14" @default.
• W4299458417 title "Photodynamic therapy using OR141-loaded nanovesicles for eradication of leukemic cells from ovarian tissue" @default.
• W4299458417 cites W1143948794 @default.
• W4299458417 cites W1963527340 @default.
• W4299458417 cites W1972116828 @default.
• W4299458417 cites W1995223391 @default.
• W4299458417 cites W2025290888 @default.
• W4299458417 cites W2053892140 @default.
• W4299458417 cites W2075129724 @default.
• W4299458417 cites W2081501602 @default.
• W4299458417 cites W2088146449 @default.
• W4299458417 cites W2121897688 @default.
• W4299458417 cites W2146136320 @default.
• W4299458417 cites W2148626043 @default.
• W4299458417 cites W2166494125 @default.
• W4299458417 cites W2321339982 @default.
• W4299458417 cites W2325020458 @default.
• W4299458417 cites W2469899335 @default.
• W4299458417 cites W2512322349 @default.
• W4299458417 cites W2564584078 @default.
• W4299458417 cites W2598927716 @default.
• W4299458417 cites W2606393834 @default.
• W4299458417 cites W2615051530 @default.
• W4299458417 cites W2621566172 @default.
• W4299458417 cites W2765221219 @default.
• W4299458417 cites W2765963789 @default.
• W4299458417 cites W2774088651 @default.
• W4299458417 cites W2775687057 @default.
• W4299458417 cites W2786090367 @default.
• W4299458417 cites W2791335613 @default.
• W4299458417 cites W2811040716 @default.
• W4299458417 cites W2884145325 @default.
• W4299458417 cites W2888538308 @default.
• W4299458417 cites W2891653767 @default.
• W4299458417 cites W2900759511 @default.
• W4299458417 cites W2908272071 @default.
• W4299458417 cites W2922738672 @default.
• W4299458417 cites W2939092940 @default.
• W4299458417 cites W2941262763 @default.
• W4299458417 cites W2964582591 @default.
• W4299458417 cites W2967210369 @default.
• W4299458417 cites W3009904823 @default.
• W4299458417 cites W3016917579 @default.
• W4299458417 cites W3108331675 @default.
• W4299458417 cites W3193980649 @default.
• W4299458417 cites W3200544664 @default.
• W4299458417 cites W3200780721 @default.
• W4299458417 cites W3204311807 @default.
• W4299458417 cites W4211024586 @default.
• W4299458417 cites W4282841638 @default.
• W4299458417 cites W4283736576 @default.
• W4299458417 cites W4283748786 @default.
• W4299458417 cites W4293206284 @default.
• W4299458417 cites W4296984762 @default.
• W4299458417 cites W2892337833 @default.
• W4299458417 doi "https://doi.org/10.1016/j.pdpdt.2022.103139" @default.
• W4299458417 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36198387" @default.
• W4299458417 hasPublicationYear "2022" @default.
• W4299458417 type Work @default.
• W4299458417 citedByCount "4" @default.
• W4299458417 countsByYear W42994584172023 @default.
• W4299458417 crossrefType "journal-article" @default.
• W4299458417 hasAuthorship W4299458417A5036421912 @default.
• W4299458417 hasAuthorship W4299458417A5054901204 @default.
• W4299458417 hasAuthorship W4299458417A5056903468 @default.
• W4299458417 hasAuthorship W4299458417A5059376263 @default.
• W4299458417 hasAuthorship W4299458417A5063029358 @default.
• W4299458417 hasAuthorship W4299458417A5067067491 @default.
• W4299458417 hasConcept C121608353 @default.
• W4299458417 hasConcept C126322002 @default.
• W4299458417 hasConcept C143998085 @default.
• W4299458417 hasConcept C150903083 @default.
• W4299458417 hasConcept C16930146 @default.
• W4299458417 hasConcept C178790620 @default.
• W4299458417 hasConcept C185592680 @default.
• W4299458417 hasConcept C207001950 @default.
• W4299458417 hasConcept C26291073 @default.
• W4299458417 hasConcept C2776960273 @default.
• W4299458417 hasConcept C2778461978 @default.
• W4299458417 hasConcept C2778729363 @default.
• W4299458417 hasConcept C2780427987 @default.
• W4299458417 hasConcept C2781323092 @default.
• W4299458417 hasConcept C28328180 @default.
• W4299458417 hasConcept C2911091166 @default.
• W4299458417 hasConcept C502942594 @default.
• W4299458417 hasConcept C54355233 @default.
• W4299458417 hasConcept C71924100 @default.
• W4299458417 hasConcept C86803240 @default.
• W4299458417 hasConceptScore W4299458417C121608353 @default.

• next