Matches in SemOpenAlex for { <https://semopenalex.org/work/W4299497613> ?p ?o ?g. }
Showing items 1 to 48 of
48
with 100 items per page.
- W4299497613 abstract "Testicular tumors in King-Holtzman hybrid rats with testicular feminization (tfm) were seen as firm, rounded masses of tissue consisting of Leydig cells, myoid cells, and fibroblast-like cells. The cytoplasm of Leydig cells contained well-developed smooth endoplasmic reticulum, pleomorphic mitochondria with numerous cristae, and many lipid droplets. Mitochondria were numerous and varied in size and shape. Their cristae were in the form of tubules, and lipid-like inclusions were frequently seen in the mitochondrial matrix. Lysosomes, rough endoplasmic reticulum, and Golgi bodies were also scattered in the cytoplasm. An in vitro study showed that more testosterone was produced in the tumor than in the testes of rats with tfm; however, the amount in both was less than normal. Testicular tumor-bearing rats with tfm exhibited slightly higher levels of plasma testosterone than did non-tumor-bearing animals with tfm. Levels in both were significantly higher than normal. Testicular tumor cells growing in culture medium supplemented with luteinizing hormone (LH) contained more protein and synthesized more androgen and DNA than did those growing in culture medium without LH. Observed under the scanning and transmission electron microscopes, the LH-stimulated cells had well-developed cytoplasmic organelles and inclusions and surface specializations such as numerous microvilli. large blebs, and other microextensions. They adhered well to the glass surface. These results indicated that Leydig cells in testicular tumors of rats with tfm had morphologic characteristics of steroid-producing cells. In addition these cells were capable of producing steroids, and this capability was enhanced by the presence of LH." @default.
- W4299497613 created "2022-10-02" @default.
- W4299497613 date "1980-07-01" @default.
- W4299497613 modified "2023-09-30" @default.
- W4299497613 title "Structural and Functional Factors Related to Testicular Neoplasia in Feminized Rats<xref ref-type=fn rid=FN2>2</xref><xref ref-type=fn rid=FN3>3</xref>" @default.
- W4299497613 doi "https://doi.org/10.1093/jnci/65.1.161" @default.
- W4299497613 hasPublicationYear "1980" @default.
- W4299497613 type Work @default.
- W4299497613 citedByCount "0" @default.
- W4299497613 crossrefType "journal-article" @default.
- W4299497613 hasConcept C119062480 @default.
- W4299497613 hasConcept C126322002 @default.
- W4299497613 hasConcept C134018914 @default.
- W4299497613 hasConcept C158617107 @default.
- W4299497613 hasConcept C185592680 @default.
- W4299497613 hasConcept C190062978 @default.
- W4299497613 hasConcept C25095133 @default.
- W4299497613 hasConcept C2779279991 @default.
- W4299497613 hasConcept C55493867 @default.
- W4299497613 hasConcept C71924100 @default.
- W4299497613 hasConcept C86803240 @default.
- W4299497613 hasConceptScore W4299497613C119062480 @default.
- W4299497613 hasConceptScore W4299497613C126322002 @default.
- W4299497613 hasConceptScore W4299497613C134018914 @default.
- W4299497613 hasConceptScore W4299497613C158617107 @default.
- W4299497613 hasConceptScore W4299497613C185592680 @default.
- W4299497613 hasConceptScore W4299497613C190062978 @default.
- W4299497613 hasConceptScore W4299497613C25095133 @default.
- W4299497613 hasConceptScore W4299497613C2779279991 @default.
- W4299497613 hasConceptScore W4299497613C55493867 @default.
- W4299497613 hasConceptScore W4299497613C71924100 @default.
- W4299497613 hasConceptScore W4299497613C86803240 @default.
- W4299497613 hasLocation W42994976131 @default.
- W4299497613 hasOpenAccess W4299497613 @default.
- W4299497613 hasPrimaryLocation W42994976131 @default.
- W4299497613 hasRelatedWork W1964938225 @default.
- W4299497613 hasRelatedWork W1990366019 @default.
- W4299497613 hasRelatedWork W2027050187 @default.
- W4299497613 hasRelatedWork W2065676653 @default.
- W4299497613 hasRelatedWork W2071366755 @default.
- W4299497613 hasRelatedWork W2119698738 @default.
- W4299497613 hasRelatedWork W2331819732 @default.
- W4299497613 hasRelatedWork W2414118883 @default.
- W4299497613 hasRelatedWork W2419349849 @default.
- W4299497613 hasRelatedWork W755786774 @default.
- W4299497613 isParatext "false" @default.
- W4299497613 isRetracted "false" @default.
- W4299497613 workType "article" @default.