Matches in SemOpenAlex for { <https://semopenalex.org/work/W4299616099> ?p ?o ?g. }
Showing items 1 to 56 of
56
with 100 items per page.
- W4299616099 endingPage "80" @default.
- W4299616099 startingPage "1871" @default.
- W4299616099 abstract "The extraordinary antiarrhythmic efficacy of amiodarone has been well documented in the last few years. Parallel investigations of the electrophysiologic influence of this iodinated benzofuran derivative on myocardial tissue showed that repolarizing as well as depolarizing currents are inhibited. However, the detailed electrochemical aspects of these effects are only partly understood. Likewise, ideas on causes of the differences in hemodynamic and electrophysiologic actions of oral and intravenous amiodarone are still speculative. An understanding of the actions of amiodarone is particularly difficult to achieve because of the unique pharmacokinetics of the drug: it resides in extra-plasmatic compartments for months after discontinuation of treatment, a fact which explains, for example, the lack of an established dose/response relationship. Replacement of amiodarone by another antiarrhythmic drug in the same patient may be problematic, because pharmacokinetic and pharmacodynamic interactions of residual amiodarone with the new antiarrhythmic drug are to be expected. Therefore, amiodarone should be prescribed only in cases where other treatment has failed. This is also advisable in view of the long list of amiodarone-induced adverse reactions. Determinations of plasma concentrations of amiodarone and desethylamiodarone may be useful in some instances, but must never replace clinical evaluation of antiarrhythmic drug efficacy. Although the incidence of some amiodarone-induced adverse reactions increases with dosage and serum drug level, dose-independent factors may play a role in the rare but serious pulmonary and hepatic side effects." @default.
- W4299616099 created "2022-10-02" @default.
- W4299616099 creator A5084136029 @default.
- W4299616099 date "1988-12-17" @default.
- W4299616099 modified "2023-09-29" @default.
- W4299616099 title "[Amiodarone]." @default.
- W4299616099 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3065934" @default.
- W4299616099 hasPublicationYear "1988" @default.
- W4299616099 type Work @default.
- W4299616099 citedByCount "0" @default.
- W4299616099 crossrefType "journal-article" @default.
- W4299616099 hasAuthorship W4299616099A5084136029 @default.
- W4299616099 hasConcept C111113717 @default.
- W4299616099 hasConcept C112705442 @default.
- W4299616099 hasConcept C126322002 @default.
- W4299616099 hasConcept C164705383 @default.
- W4299616099 hasConcept C197934379 @default.
- W4299616099 hasConcept C2778094803 @default.
- W4299616099 hasConcept C2778715236 @default.
- W4299616099 hasConcept C2779161974 @default.
- W4299616099 hasConcept C2780035454 @default.
- W4299616099 hasConcept C42219234 @default.
- W4299616099 hasConcept C71924100 @default.
- W4299616099 hasConcept C98274493 @default.
- W4299616099 hasConceptScore W4299616099C111113717 @default.
- W4299616099 hasConceptScore W4299616099C112705442 @default.
- W4299616099 hasConceptScore W4299616099C126322002 @default.
- W4299616099 hasConceptScore W4299616099C164705383 @default.
- W4299616099 hasConceptScore W4299616099C197934379 @default.
- W4299616099 hasConceptScore W4299616099C2778094803 @default.
- W4299616099 hasConceptScore W4299616099C2778715236 @default.
- W4299616099 hasConceptScore W4299616099C2779161974 @default.
- W4299616099 hasConceptScore W4299616099C2780035454 @default.
- W4299616099 hasConceptScore W4299616099C42219234 @default.
- W4299616099 hasConceptScore W4299616099C71924100 @default.
- W4299616099 hasConceptScore W4299616099C98274493 @default.
- W4299616099 hasIssue "50" @default.
- W4299616099 hasLocation W42996160991 @default.
- W4299616099 hasOpenAccess W4299616099 @default.
- W4299616099 hasPrimaryLocation W42996160991 @default.
- W4299616099 hasRelatedWork W1978032370 @default.
- W4299616099 hasRelatedWork W1979757582 @default.
- W4299616099 hasRelatedWork W2071747460 @default.
- W4299616099 hasRelatedWork W2090099591 @default.
- W4299616099 hasRelatedWork W2227061539 @default.
- W4299616099 hasRelatedWork W2332367370 @default.
- W4299616099 hasRelatedWork W2400461952 @default.
- W4299616099 hasRelatedWork W2811032560 @default.
- W4299616099 hasRelatedWork W1914240745 @default.
- W4299616099 hasRelatedWork W2603979525 @default.
- W4299616099 hasVolume "118" @default.
- W4299616099 isParatext "false" @default.
- W4299616099 isRetracted "false" @default.
- W4299616099 workType "article" @default.