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- W4299686523 abstract "Endothelial cells have been established to generate intercellular stresses and tractions, but the role gap junctions play in endothelial intercellular stress and traction generation is currently unknown. Therefore, we present here a mechanics-based protocol to probe the influence of gap junction connexin 43 (Cx43) has on endothelial biomechanics by exposing confluent endothelial monolayers to a known Cx43 inhibitor 2,5-dihydroxychalcone (chalcone) and measuring the impact this inhibitor has on tractions and intercellular stresses. We present representative results, which show a decrease in both tractions and intercellular stresses under a high chalcone dosage (2 µg/mL) when compared to control. This protocol can be applied to not just Cx43, but also other gap junctions as well, assuming the appropriate inhibitor is used. We believe this protocol will be useful in the fields of cardiovascular and mechanobiology research." @default.
- W4299686523 created "2022-10-02" @default.
- W4299686523 creator A5031752233 @default.
- W4299686523 creator A5040303193 @default.
- W4299686523 date "2019-10-04" @default.
- W4299686523 modified "2023-09-27" @default.
- W4299686523 title "Perturbing Endothelial Biomechanics via Connexin 43 Structural Disruption" @default.
- W4299686523 doi "https://doi.org/10.3791/60034-v" @default.
- W4299686523 hasPublicationYear "2019" @default.
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