FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4299878831> ?p ?o ?g. }

• W4299878831 endingPage "117" @default.
• W4299878831 startingPage "112" @default.
• W4299878831 abstract "Introduction The discontinuation of disease-modifying therapies (DMTs) in multiple sclerosis (MS) is commonly seen in real-world settings due to several factors.Area cover The aim of this study is to describe the frequency of disease activity after discontinuation of DMTs in MS patients included in the Argentinean MS and NMOSD registry.Discusion Patients with relapsing remitting MS (RRMS) and active secondary progressive MS (SPMS) were included based on the following criteria: they discontinued treatment for more than 6 months, they had been treated with a DMT for ≥2 years, and they had at least 6 months of follow-up in the registry after discontinuation. Demographic and clinical data were collected. Disease activity during follow-up was defined as the presence of a clinical relapse or a new magnetic resonance (MRI) lesion (either new lesions on T2-weighted sequence and/or contrast enhancement). Bivariate analysis was applied to identify clinical and demographic factors related to disease activity.Conclusion We included 377 patients (75.5% RRMS, 22.5% SPMS) who had discontinued DMTs. The mean (SD) follow-up after discontinuation was 15.7 (7.9) months. After discontinuation, the presence of relapse was detected in 18.8% and 3.5% in RRMS and SPMS, respectively; and new MRI activity in 22% and 3.5%, respectively. We found that higher risk of relapse and MRI activity was associated with younger age (p < 0.001), shorter disease duration (p < 0.001), and RRMS phenotype (p = 0.006). Males showed higher MRI activity (p 0.011). This study provides real-world data that can guide physicians when considering discontinuation of DMTs." @default.
• W4299878831 created "2022-10-03" @default.
• W4299878831 creator A5000611755 @default.
• W4299878831 creator A5004456380 @default.
• W4299878831 creator A5005322774 @default.
• W4299878831 creator A5015097496 @default.
• W4299878831 creator A5016995020 @default.
• W4299878831 creator A5020180923 @default.
• W4299878831 creator A5022666378 @default.
• W4299878831 creator A5024208673 @default.
• W4299878831 creator A5025448045 @default.
• W4299878831 creator A5027171153 @default.
• W4299878831 creator A5030272623 @default.
• W4299878831 creator A5030485241 @default.
• W4299878831 creator A5031773319 @default.
• W4299878831 creator A5033609584 @default.
• W4299878831 creator A5033974288 @default.
• W4299878831 creator A5036236307 @default.
• W4299878831 creator A5036278441 @default.
• W4299878831 creator A5036671827 @default.
• W4299878831 creator A5037757305 @default.
• W4299878831 creator A5039510018 @default.
• W4299878831 creator A5040887923 @default.
• W4299878831 creator A5041152006 @default.
• W4299878831 creator A5041875047 @default.
• W4299878831 creator A5043309185 @default.
• W4299878831 creator A5043576396 @default.
• W4299878831 creator A5046212276 @default.
• W4299878831 creator A5047408530 @default.
• W4299878831 creator A5050537760 @default.
• W4299878831 creator A5051109514 @default.
• W4299878831 creator A5051865755 @default.
• W4299878831 creator A5052232552 @default.
• W4299878831 creator A5053154180 @default.
• W4299878831 creator A5053251374 @default.
• W4299878831 creator A5053448786 @default.
• W4299878831 creator A5053483820 @default.
• W4299878831 creator A5056436816 @default.
• W4299878831 creator A5059692404 @default.
• W4299878831 creator A5059829761 @default.
• W4299878831 creator A5060030050 @default.
• W4299878831 creator A5060530662 @default.
• W4299878831 creator A5061158083 @default.
• W4299878831 creator A5062498993 @default.
• W4299878831 creator A5063726982 @default.
• W4299878831 creator A5068908441 @default.
• W4299878831 creator A5071850413 @default.
• W4299878831 creator A5074852576 @default.
• W4299878831 creator A5075843930 @default.
• W4299878831 creator A5080256315 @default.
• W4299878831 creator A5081701168 @default.
• W4299878831 creator A5085188215 @default.
• W4299878831 creator A5086070678 @default.
• W4299878831 creator A5090063432 @default.
• W4299878831 creator A5090383196 @default.
• W4299878831 creator A5090711447 @default.
• W4299878831 date "2022-10-02" @default.
• W4299878831 modified "2023-10-15" @default.
• W4299878831 title "Disease activity after discontinuation of disease-modifying therapies in patients with multiple sclerosis in Argentina: data from the nationwide registry RelevarEM" @default.
• W4299878831 cites W1974743586 @default.
• W4299878831 cites W1987011790 @default.
• W4299878831 cites W1997880566 @default.
• W4299878831 cites W2011804082 @default.
• W4299878831 cites W2031915800 @default.
• W4299878831 cites W2064985118 @default.
• W4299878831 cites W2094054210 @default.
• W4299878831 cites W2097669496 @default.
• W4299878831 cites W2099893652 @default.
• W4299878831 cites W2103758700 @default.
• W4299878831 cites W2105206040 @default.
• W4299878831 cites W2130355701 @default.
• W4299878831 cites W2138175270 @default.
• W4299878831 cites W2144120881 @default.
• W4299878831 cites W2146236437 @default.
• W4299878831 cites W2289114798 @default.
• W4299878831 cites W2406486993 @default.
• W4299878831 cites W2429537896 @default.
• W4299878831 cites W2516226399 @default.
• W4299878831 cites W2533767944 @default.
• W4299878831 cites W2538821230 @default.
• W4299878831 cites W2733599108 @default.
• W4299878831 cites W2777074421 @default.
• W4299878831 cites W2791181325 @default.
• W4299878831 cites W2896455370 @default.
• W4299878831 cites W2944846680 @default.
• W4299878831 cites W2963953516 @default.
• W4299878831 cites W3084666553 @default.
• W4299878831 cites W3093484187 @default.
• W4299878831 cites W4319308236 @default.
• W4299878831 doi "https://doi.org/10.1080/01616412.2022.2124792" @default.
• W4299878831 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36184106" @default.
• W4299878831 hasPublicationYear "2022" @default.
• W4299878831 type Work @default.
• W4299878831 citedByCount "1" @default.
• W4299878831 countsByYear W42998788312023 @default.
• W4299878831 crossrefType "journal-article" @default.
• W4299878831 hasAuthorship W4299878831A5000611755 @default.
• W4299878831 hasAuthorship W4299878831A5004456380 @default.

• next