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• W4299903658 abstract "Abstract We evaluated an automated chemiluminescence immunoassay (CLIA) developed for the measurement of urinary free deoxypyridinoline (DPD). The new DPD method by CLIA is based on the competition of DPD with particle-bound pyridinoline for a limited amount of monoclonal mouse anti-DPD antibody. Total imprecision (CV) was 3.2–9.0% at 30–270 nmol/L. Regression analysis of urinary DPD concentration (second morning-void) measured by CLIA (y) and enzyme immunoassay (EIA) for adult volunteers (n = 449) with and without bone disease revealed a best fit equation of: y = 1.08 ± 0.03x − 1.15 ± 0.98 nmol/L (r = 0.964, Sy‖x = 14 nmol/L). CLIA and EIA methods were correlated with HPLC measurement of urinary free DPD (r = 0.846 and 0.871, respectively). For healthy adults, the creatinine-normalized excretion of DPD (mean ± SD) measured by CLIA for 61 men (4.1 ± 1.2 μmol DPD/mol creatinine) and 76 premenopausal women (5.3 ± 1.8 μmol DPD/mol creatinine) did not differ significantly (P &gt;0.05) from DPD excretion measured by EIA, and both immunoassays showed a significant gender difference (P &lt;0.001) in reference intervals. In a clinical trial, DPD excretion (μmol DPD/mol creatinine) measured by CLIA differed substantially from the reference population for 54 untreated pagetic (12.7 ± 8.0 SD), 255 untreated osteoporotic (7.5 ± 4.1), 21 osteomalacic (12.4 ± 8.5), 17 primary hyperparathyroid (9.4 ± 4.4), and 14 secondary hyperparathyroid (9.2 ± 5.1) patients. Clinical sensitivities of the CLIA and EIA methods range from 38% to 80% in bone disorders and limit the use of the DPD measurement in disease detection. DPD excretion after pamidronate treatment in a subgroup of the pagetic patients fell dramatically as assessed by CLIA or EIA. We conclude that the automated CLIA method for DPD is a convenient and reliable method that may aid in the evaluation and management of bone disease and is applicable to high volume testing in the routine clinical laboratory." @default.
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• W4299903658 date "1998-10-01" @default.
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• W4299903658 title "Urinary free deoxypyridinoline by chemiluminescence immunoassay: analytical and clinical evaluation" @default.
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• W4299903658 doi "https://doi.org/10.1093/clinchem/44.10.2126" @default.
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