FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4299956404> ?p ?o ?g. }

• W4299956404 abstract "From the point of conformation, kinetics, and function, human serum albumin (HSA) is an effectively characterized serum protein. Therefore, it has been used broadly in the study of biotechnology and pharmaceutical fields. On the understanding of the protein-drug interactions, it can become the main potential target. The study aims to gain a biophysical sight in the interaction of HSA with Everolimus (Evo), a potent macrolide immunosuppressant agent. Evo has been shown to be effective against various cancers and is used alone or in combination with other drugs to prevent the rejection of organ transplants. Various spectroscopic approaches, including emission, synchronous fluorescence, three-dimensional fluorescence, Fourier transform infrared spectroscopy, UV-visible spectroscopy, circular dichroism, and zeta potential methods, were used in this investigation under physiological settings. Based on the fluorescence quenching process, binding constants (Ka) and binding sites (n) were found using a modified Stern-Volmer analysis at three different temperatures. The thermodynamic parameters of entropy change (ΔS), the enthalpy change (ΔH), and free energy change (ΔG) are calculated using the van’t Hoff equation. The Förster theory was used to calculate the binding distance between HSA and Evo. To validate conformational changes in HSA under the impact of Evo, researchers used three-dimensional fluorescence, synchronous fluorescence, Fourier transform infrared spectra, circular dichroism spectroscopy, and ultraviolet-visible absorbance spectroscopy. Moreover, the zeta potential of binding of HSA to Evo was determined in the pH = 7.4. All results are vital to the pharmacodynamic and pharmacokinetic study of Everolimus and its further developments." @default.
• W4299956404 created "2022-10-03" @default.
• W4299956404 creator A5010852221 @default.
• W4299956404 creator A5020123560 @default.
• W4299956404 creator A5027049288 @default.
• W4299956404 creator A5029548562 @default.
• W4299956404 creator A5038371168 @default.
• W4299956404 date "2022-01-01" @default.
• W4299956404 modified "2023-10-17" @default.
• W4299956404 title "Spectroscopic analysis of everolimus and human serum albumin interaction" @default.
• W4299956404 cites W1971942980 @default.
• W4299956404 cites W1974630059 @default.
• W4299956404 cites W1985282657 @default.
• W4299956404 cites W1986562095 @default.
• W4299956404 cites W1995802373 @default.
• W4299956404 cites W1996004804 @default.
• W4299956404 cites W2008078741 @default.
• W4299956404 cites W2040184556 @default.
• W4299956404 cites W2040228567 @default.
• W4299956404 cites W2041317621 @default.
• W4299956404 cites W2046118342 @default.
• W4299956404 cites W2075705506 @default.
• W4299956404 cites W2099073545 @default.
• W4299956404 cites W2130708076 @default.
• W4299956404 cites W2209368665 @default.
• W4299956404 cites W2403104888 @default.
• W4299956404 cites W2561853437 @default.
• W4299956404 cites W2738564519 @default.
• W4299956404 cites W869793459 @default.
• W4299956404 doi "https://doi.org/10.1063/5.0098027" @default.
• W4299956404 hasPublicationYear "2022" @default.
• W4299956404 type Work @default.
• W4299956404 citedByCount "0" @default.
• W4299956404 crossrefType "proceedings-article" @default.
• W4299956404 hasAuthorship W4299956404A5010852221 @default.
• W4299956404 hasAuthorship W4299956404A5020123560 @default.
• W4299956404 hasAuthorship W4299956404A5027049288 @default.
• W4299956404 hasAuthorship W4299956404A5029548562 @default.
• W4299956404 hasAuthorship W4299956404A5038371168 @default.
• W4299956404 hasBestOaLocation W42999564041 @default.
• W4299956404 hasConcept C113196181 @default.
• W4299956404 hasConcept C121332964 @default.
• W4299956404 hasConcept C121745418 @default.
• W4299956404 hasConcept C12554922 @default.
• W4299956404 hasConcept C127413603 @default.
• W4299956404 hasConcept C133571119 @default.
• W4299956404 hasConcept C155672457 @default.
• W4299956404 hasConcept C158711907 @default.
• W4299956404 hasConcept C160892712 @default.
• W4299956404 hasConcept C171250308 @default.
• W4299956404 hasConcept C185592680 @default.
• W4299956404 hasConcept C192562407 @default.
• W4299956404 hasConcept C2778597219 @default.
• W4299956404 hasConcept C32891209 @default.
• W4299956404 hasConcept C42360764 @default.
• W4299956404 hasConcept C43617362 @default.
• W4299956404 hasConcept C55493867 @default.
• W4299956404 hasConcept C62520636 @default.
• W4299956404 hasConcept C62614982 @default.
• W4299956404 hasConcept C8010536 @default.
• W4299956404 hasConcept C86181022 @default.
• W4299956404 hasConcept C86803240 @default.
• W4299956404 hasConcept C91881484 @default.
• W4299956404 hasConcept C98015330 @default.
• W4299956404 hasConceptScore W4299956404C113196181 @default.
• W4299956404 hasConceptScore W4299956404C121332964 @default.
• W4299956404 hasConceptScore W4299956404C121745418 @default.
• W4299956404 hasConceptScore W4299956404C12554922 @default.
• W4299956404 hasConceptScore W4299956404C127413603 @default.
• W4299956404 hasConceptScore W4299956404C133571119 @default.
• W4299956404 hasConceptScore W4299956404C155672457 @default.
• W4299956404 hasConceptScore W4299956404C158711907 @default.
• W4299956404 hasConceptScore W4299956404C160892712 @default.
• W4299956404 hasConceptScore W4299956404C171250308 @default.
• W4299956404 hasConceptScore W4299956404C185592680 @default.
• W4299956404 hasConceptScore W4299956404C192562407 @default.
• W4299956404 hasConceptScore W4299956404C2778597219 @default.
• W4299956404 hasConceptScore W4299956404C32891209 @default.
• W4299956404 hasConceptScore W4299956404C42360764 @default.
• W4299956404 hasConceptScore W4299956404C43617362 @default.
• W4299956404 hasConceptScore W4299956404C55493867 @default.
• W4299956404 hasConceptScore W4299956404C62520636 @default.
• W4299956404 hasConceptScore W4299956404C62614982 @default.
• W4299956404 hasConceptScore W4299956404C8010536 @default.
• W4299956404 hasConceptScore W4299956404C86181022 @default.
• W4299956404 hasConceptScore W4299956404C86803240 @default.
• W4299956404 hasConceptScore W4299956404C91881484 @default.
• W4299956404 hasConceptScore W4299956404C98015330 @default.
• W4299956404 hasLocation W42999564041 @default.
• W4299956404 hasOpenAccess W4299956404 @default.
• W4299956404 hasPrimaryLocation W42999564041 @default.
• W4299956404 hasRelatedWork W1564526509 @default.
• W4299956404 hasRelatedWork W2057831367 @default.
• W4299956404 hasRelatedWork W2063326110 @default.
• W4299956404 hasRelatedWork W2099481040 @default.
• W4299956404 hasRelatedWork W2366818363 @default.
• W4299956404 hasRelatedWork W2376183131 @default.
• W4299956404 hasRelatedWork W2378936578 @default.
• W4299956404 hasRelatedWork W2389828761 @default.
• W4299956404 hasRelatedWork W2804738953 @default.

• next