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- W4299968638 abstract "The metabolism of progesterone by the central nervous system, pituitary gland, and uterus was investigated. Specific regions of the rat brain were incubated in tritiated-progesterone. The primary metabolites identified were 5alpha-pregnane-3,20-dione, 3alpha-hydroxy-5alpha-pregnan-20-one, and 20alpha-hydroxy-4-pregnen-3-one, which indicates that the enzymes delta-4-steroid 5alpha reductase, 3alpha-hydroxysteroid dehydrogenase, and 20alpha-hydroxysteroid dehydrogenase are present in these tissues. Progesterone was recovered mostly unchanged from the uterus, medial basal hypothalamus, cerebral cortex, and muscle, but was mostly transformed to 5alpha-dihydroprogesterone in the pituitary. Most of the 5alpha-dihydrotestosterone in the uterus, cortex, and muscle tissue was recovered as 3alpha-hydroxy-5alpha-pregnan-20-one, while that in the pituitary and medial basal hypothalamus was mostly unconverted. Levels of progesterone were generally similar in tissue and plasma, whereas 5alpha-dihydroprogesterone was present in much greater amounts in the pituitary and hypothalamus, but not in the uterus, plasma, or tissue." @default.
- W4299968638 created "2022-10-03" @default.
- W4299968638 date "1977-05-01" @default.
- W4299968638 modified "2023-09-29" @default.
- W4299968638 title "Metabolism of progesterone by the central nervous system, pituitary gland and uterus." @default.
- W4299968638 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12326806" @default.
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