Matches in SemOpenAlex for { <https://semopenalex.org/work/W4300003392> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W4300003392 abstract "Abstract Background Meningiomas are common primary brain neoplasms. CD44 is a cell surface glycoprotein receptor that is involved in matrix-mediated cell signaling and cell–matrix adhesion. Matrix metalloproteinase-9 (MMP-9) plays important role in angiogenesis and tumor invasion. The expression of CD44 protein membranous and cytoplasmic (CD44M and CD44C) has been reported in several tumors (such as lobular carcinoma, renal cell carcinoma, sinonasal melanoma, and lymphoma) except CNS tumors. Methods This study addressed the expression of CD44M and CD44C and MMP9 proteins in intracranial meningiomas and their relationship to overall survival. The expression patterns of CD44M&C and MMP-9 proteins were examined in 32 cases of benign meningiomas, 12 cases of atypical meningiomas, and 6 cases of anaplastic meningiomas using immunohistochemical staining methods. Results There was more evidence of CD44M expression in atypical and anaplastic meningioma ( p = < 0.001). Interestingly, Spearman correlation analyses revealed significant positive correlation between CD44M and MMP9 protein ( r = 0.572, p = < 0.001) in spite of the negative correlation between MMP9 and CD44 score ( r = − 0.035 p = 0.405). There was a significant association between Ki67 protein expression and the grade of meningiomas ( p < 0.001) and gender ( p = 0.026). There was a significant correlation between overall survival (OS) and age, gender, tumor grade, and Ki-67. Conclusions Extensive CD44M expression in high-grade meningioma may reflect a tendency toward more invasive power of meningioma cells into surrounding structures (dura, bone, and brain).CD44M/MMP-9 axis presented by this study is open for future investigations." @default.
- W4300003392 created "2022-10-03" @default.
- W4300003392 creator A5021240898 @default.
- W4300003392 creator A5038064547 @default.
- W4300003392 creator A5058189294 @default.
- W4300003392 creator A5058930826 @default.
- W4300003392 date "2022-10-03" @default.
- W4300003392 modified "2023-10-14" @default.
- W4300003392 title "Novel evaluation of the expression patterns CD44 and MMP9 proteins in intracranial meningiomas and their relationship to the overall survival" @default.
- W4300003392 cites W1517179520 @default.
- W4300003392 cites W1987873750 @default.
- W4300003392 cites W1995086015 @default.
- W4300003392 cites W1999658780 @default.
- W4300003392 cites W1999798556 @default.
- W4300003392 cites W2004645067 @default.
- W4300003392 cites W2010609802 @default.
- W4300003392 cites W2028514589 @default.
- W4300003392 cites W2029994214 @default.
- W4300003392 cites W2040084628 @default.
- W4300003392 cites W2044554064 @default.
- W4300003392 cites W2046383500 @default.
- W4300003392 cites W2048171546 @default.
- W4300003392 cites W2049117179 @default.
- W4300003392 cites W2068239779 @default.
- W4300003392 cites W2076173075 @default.
- W4300003392 cites W2076345394 @default.
- W4300003392 cites W2077173562 @default.
- W4300003392 cites W2077997501 @default.
- W4300003392 cites W2085601724 @default.
- W4300003392 cites W2086159524 @default.
- W4300003392 cites W2112327424 @default.
- W4300003392 cites W2117721992 @default.
- W4300003392 cites W2123641443 @default.
- W4300003392 cites W2143904769 @default.
- W4300003392 cites W2144918550 @default.
- W4300003392 cites W2602092987 @default.
- W4300003392 cites W2734406175 @default.
- W4300003392 cites W2807932567 @default.
- W4300003392 cites W2906607383 @default.
- W4300003392 cites W2943737896 @default.
- W4300003392 cites W3010159770 @default.
- W4300003392 cites W3027453227 @default.
- W4300003392 cites W3155189231 @default.
- W4300003392 doi "https://doi.org/10.1186/s41984-022-00173-x" @default.
- W4300003392 hasPublicationYear "2022" @default.
- W4300003392 type Work @default.
- W4300003392 citedByCount "0" @default.
- W4300003392 crossrefType "journal-article" @default.
- W4300003392 hasAuthorship W4300003392A5021240898 @default.
- W4300003392 hasAuthorship W4300003392A5038064547 @default.
- W4300003392 hasAuthorship W4300003392A5058189294 @default.
- W4300003392 hasAuthorship W4300003392A5058930826 @default.
- W4300003392 hasBestOaLocation W43000033921 @default.
- W4300003392 hasConcept C104317684 @default.
- W4300003392 hasConcept C127561419 @default.
- W4300003392 hasConcept C142724271 @default.
- W4300003392 hasConcept C1491633281 @default.
- W4300003392 hasConcept C204232928 @default.
- W4300003392 hasConcept C2775997469 @default.
- W4300003392 hasConcept C2779160599 @default.
- W4300003392 hasConcept C2780394083 @default.
- W4300003392 hasConcept C2780932548 @default.
- W4300003392 hasConcept C502942594 @default.
- W4300003392 hasConcept C54355233 @default.
- W4300003392 hasConcept C55493867 @default.
- W4300003392 hasConcept C71924100 @default.
- W4300003392 hasConcept C86803240 @default.
- W4300003392 hasConceptScore W4300003392C104317684 @default.
- W4300003392 hasConceptScore W4300003392C127561419 @default.
- W4300003392 hasConceptScore W4300003392C142724271 @default.
- W4300003392 hasConceptScore W4300003392C1491633281 @default.
- W4300003392 hasConceptScore W4300003392C204232928 @default.
- W4300003392 hasConceptScore W4300003392C2775997469 @default.
- W4300003392 hasConceptScore W4300003392C2779160599 @default.
- W4300003392 hasConceptScore W4300003392C2780394083 @default.
- W4300003392 hasConceptScore W4300003392C2780932548 @default.
- W4300003392 hasConceptScore W4300003392C502942594 @default.
- W4300003392 hasConceptScore W4300003392C54355233 @default.
- W4300003392 hasConceptScore W4300003392C55493867 @default.
- W4300003392 hasConceptScore W4300003392C71924100 @default.
- W4300003392 hasConceptScore W4300003392C86803240 @default.
- W4300003392 hasIssue "1" @default.
- W4300003392 hasLocation W43000033921 @default.
- W4300003392 hasLocation W43000033922 @default.
- W4300003392 hasOpenAccess W4300003392 @default.
- W4300003392 hasPrimaryLocation W43000033921 @default.
- W4300003392 hasRelatedWork W2068239779 @default.
- W4300003392 hasRelatedWork W2070910363 @default.
- W4300003392 hasRelatedWork W2084490580 @default.
- W4300003392 hasRelatedWork W2119426718 @default.
- W4300003392 hasRelatedWork W2121529430 @default.
- W4300003392 hasRelatedWork W2348325691 @default.
- W4300003392 hasRelatedWork W2386801676 @default.
- W4300003392 hasRelatedWork W4225327042 @default.
- W4300003392 hasRelatedWork W4300003392 @default.
- W4300003392 hasRelatedWork W4367179324 @default.
- W4300003392 hasVolume "37" @default.
- W4300003392 isParatext "false" @default.
- W4300003392 isRetracted "false" @default.
- W4300003392 workType "article" @default.