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- W43001540 abstract "The microtubule (MT) system is important for many aspects of neuronal function, including motility, differentiation, and organelle trafficking. The dysregulation of this system can therefore have a significant impact on neuronal function and survival. Parkinson’s disease (PD) is associated with alterations in integrity of the axon/dendrites as well as axonal transport, which is suggestive of altered MT function. In fact, recent studies using genetic and toxin models are beginning to implicate MT dysfunction as a key mechanism underlying neuronal degeneration in PD. To further study the role of MT dysfunction in PD neurodegeneration, the effects of oxidative stress, which plays a key role in PD pathogenesis, on MT function were examined using the commonly utilized PD toxin, 6-hydroxydopamine (6OHDA). In response to 6OHDA-induced oxidative stress in neuronal cells, significant alterations in MT function were observed with reductions in MT growth rate, increase in frequency of MT pauses/retractions, impaired end binding protein 1 (EB1) levels, and increase in levels of tubulin acetylation. Impaired function of tubulin deacetylases, specifically sirtuin 2 (SIRT2), was observed in oxidatively-stressed cells. Restoration of tubulin deacetylase function rescued MT function and the neuritic degeneration phenotype observed in response to 6OHDA, suggesting that oxidative stress impairs MT function by altering tubulin acetylation. In addition to its impact on the integrity of the neurite, oxidative disruption of MT function also affected MT-dependent nuclear transport, which could contribute to the selective declines in transcriptional responses of diseased dopaminergic neurons. In all, this study provides support for the role of MT dysfunction in the degenerative processes seen in PD. Elucidating how oxidative stress-induced changes in MT function can lead to neuronal degeneration will provide key insight into the development of novel therapeutic strategies." @default.
- W43001540 created "2016-06-24" @default.
- W43001540 creator A5040366821 @default.
- W43001540 date "2012-07-18" @default.
- W43001540 modified "2023-09-23" @default.
- W43001540 title "MICROTUBULE DYNAMICS IN OXIDATIVELY-STRESSED NEURONAL CELLS" @default.
- W43001540 cites W116026932 @default.
- W43001540 cites W1452893412 @default.
- W43001540 cites W1485428386 @default.
- W43001540 cites W1486762479 @default.
- W43001540 cites W149540474 @default.
- W43001540 cites W1518891633 @default.
- W43001540 cites W1530572244 @default.
- W43001540 cites W1531843401 @default.
- W43001540 cites W1544906050 @default.
- W43001540 cites W1585324347 @default.
- W43001540 cites W1594281994 @default.
- W43001540 cites W1599464745 @default.
- W43001540 cites W1601675369 @default.
- W43001540 cites W1791420399 @default.
- W43001540 cites W1863422003 @default.
- W43001540 cites W1864905496 @default.
- W43001540 cites W194259247 @default.
- W43001540 cites W1945804473 @default.
- W43001540 cites W1946523045 @default.
- W43001540 cites W1963639964 @default.
- W43001540 cites W1965122438 @default.
- W43001540 cites W1965625220 @default.
- W43001540 cites W1968576323 @default.
- W43001540 cites W1969342645 @default.
- W43001540 cites W1970554352 @default.
- W43001540 cites W1970878854 @default.
- W43001540 cites W1972108431 @default.
- W43001540 cites W1973321484 @default.
- W43001540 cites W1974403366 @default.
- W43001540 cites W1975255808 @default.
- W43001540 cites W1977831138 @default.
- W43001540 cites W1978705545 @default.
- W43001540 cites W1981549228 @default.
- W43001540 cites W1981610812 @default.
- W43001540 cites W1981819503 @default.
- W43001540 cites W1983353338 @default.
- W43001540 cites W1984167248 @default.
- W43001540 cites W1985501881 @default.
- W43001540 cites W1989277130 @default.
- W43001540 cites W1989734945 @default.
- W43001540 cites W1990929380 @default.
- W43001540 cites W1991302158 @default.
- W43001540 cites W1991917654 @default.
- W43001540 cites W1992027492 @default.
- W43001540 cites W1992329706 @default.
- W43001540 cites W1992483894 @default.
- W43001540 cites W1992978140 @default.
- W43001540 cites W1992998321 @default.
- W43001540 cites W1994345832 @default.
- W43001540 cites W1994924724 @default.
- W43001540 cites W1996285410 @default.
- W43001540 cites W1996311437 @default.
- W43001540 cites W1996397101 @default.
- W43001540 cites W1996982933 @default.
- W43001540 cites W1997145609 @default.
- W43001540 cites W1997564419 @default.
- W43001540 cites W1997673335 @default.
- W43001540 cites W1998988663 @default.
- W43001540 cites W1999499099 @default.
- W43001540 cites W2000022451 @default.
- W43001540 cites W2000862968 @default.
- W43001540 cites W2002865057 @default.
- W43001540 cites W2003388226 @default.
- W43001540 cites W2004280801 @default.
- W43001540 cites W2004698905 @default.
- W43001540 cites W2005789183 @default.
- W43001540 cites W2007635795 @default.
- W43001540 cites W2008861128 @default.
- W43001540 cites W2010222743 @default.
- W43001540 cites W2011789768 @default.
- W43001540 cites W2012807391 @default.
- W43001540 cites W2013037750 @default.
- W43001540 cites W2013144709 @default.
- W43001540 cites W2014613038 @default.
- W43001540 cites W2015656249 @default.
- W43001540 cites W2016010817 @default.
- W43001540 cites W2018290969 @default.
- W43001540 cites W2018319486 @default.
- W43001540 cites W2019845642 @default.
- W43001540 cites W2021258666 @default.
- W43001540 cites W2021815999 @default.
- W43001540 cites W2022136169 @default.
- W43001540 cites W2024449044 @default.
- W43001540 cites W2025541607 @default.
- W43001540 cites W2027382153 @default.
- W43001540 cites W2027675155 @default.
- W43001540 cites W2028377541 @default.
- W43001540 cites W2029246446 @default.
- W43001540 cites W2029364439 @default.
- W43001540 cites W2029777052 @default.
- W43001540 cites W2030136187 @default.
- W43001540 cites W2030378751 @default.
- W43001540 cites W2030994423 @default.
- W43001540 cites W2031426329 @default.