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- W4300165000 abstract "The 1998 Retrovirus Conference in Chicago, while not providing any major breakthroughs, confirmed the impact of combination therapy in dramatically reducing viral load in the blood and lymph nodes and increasing CD4+ and other blood cell counts. Companies are beginning to test their drugs using a user-friendly twice-daily schedule and are providing more information about new drugs. Side effects of protease inhibitors are also becoming better documented. The Conference revealed two trends in protease inhibitor use: the increased simultaneous use of two protease inhibitors (PIs) and the switch to twice-daily dosing for some drugs. Several studies involving double combinations of PIs are highlighted, including nelfinavir/indinavir, nelfinavir/saquinavir, and ritonavir/saquinavir. The dosage combinations that work best are still unclear, but physicians seem to have the most experience with ritonavir/saquinavir. Reports indicated that the best results of anti-HIV therapy are reported in people who are using the drugs for the first time. Researchers are still uncertain as to why some HIV-infected people develop AIDS and others do not, and are still unclear as to how protease inhibitors affect the immune system." @default.
- W4300165000 created "2022-10-03" @default.
- W4300165000 date "1998-04-01" @default.
- W4300165000 modified "2023-10-18" @default.
- W4300165000 title "Combinations of protease inhibitors." @default.
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