Matches in SemOpenAlex for { <https://semopenalex.org/work/W4300166883> ?p ?o ?g. }
- W4300166883 abstract "Invariant natural killer T (iNKT) cells mediate immune responses when stimulated by glycolipid agonists presented by CD1d. In extensive studies of synthetic analogues of α-galactosyl ceramides, we identified numerous examples of significant differences in the recognition of specific glycolipids in wild type mice versus human iNKT cell clones or PBMC samples. To predict human iNKT cell responses more accurately in a mouse model, we derived a mouse line in which compound genetic modifications were used to express a human-like iNKT cell TCR along with human CD1d in place of the endogenous mouse proteins. Detailed transcriptional and phenotypic profiling demonstrated that these partially humanized mice developed an expanded population of T cells recognizing CD1d-presented glycolipid antigens, among which a subset characterized by expression of chemokine receptor CXCR6 had features characteristic of authentic iNKT cells. Responses to iNKT cell activating glycolipids in these mice generated cytokine production in vitro and in vivo that showed a pattern of fine specificity that closely resembled that of cultured human iNKT cell clones. Anti-tumor responses to variants of α-galactosyl ceramide in VαKI mice also correlated with their potency for stimulating human iNKT cells. This genetically modified mouse line provides a practical model for human presentation and recognition of iNKT cell activators in the context of a normally functioning immune system, and may furnish valuable opportunities for preclinical evaluation of iNKT cell-based therapies." @default.
- W4300166883 created "2022-10-03" @default.
- W4300166883 creator A5016158429 @default.
- W4300166883 creator A5016293777 @default.
- W4300166883 creator A5038080781 @default.
- W4300166883 creator A5056330567 @default.
- W4300166883 creator A5058424034 @default.
- W4300166883 creator A5078970596 @default.
- W4300166883 creator A5080710418 @default.
- W4300166883 date "2022-10-03" @default.
- W4300166883 modified "2023-10-14" @default.
- W4300166883 title "A humanized mouse model for in vivo evaluation of invariant Natural Killer T cell responses" @default.
- W4300166883 cites W1538172952 @default.
- W4300166883 cites W1594342761 @default.
- W4300166883 cites W1768853402 @default.
- W4300166883 cites W1867592476 @default.
- W4300166883 cites W1901076689 @default.
- W4300166883 cites W1966344619 @default.
- W4300166883 cites W1975329879 @default.
- W4300166883 cites W1980547668 @default.
- W4300166883 cites W1989626793 @default.
- W4300166883 cites W2004687347 @default.
- W4300166883 cites W2008515657 @default.
- W4300166883 cites W2038057643 @default.
- W4300166883 cites W2040593694 @default.
- W4300166883 cites W2043034045 @default.
- W4300166883 cites W2051568453 @default.
- W4300166883 cites W2053431716 @default.
- W4300166883 cites W2062533437 @default.
- W4300166883 cites W2067128215 @default.
- W4300166883 cites W2067822001 @default.
- W4300166883 cites W2078613264 @default.
- W4300166883 cites W2082862556 @default.
- W4300166883 cites W2086945463 @default.
- W4300166883 cites W2090580631 @default.
- W4300166883 cites W2100875153 @default.
- W4300166883 cites W2110476061 @default.
- W4300166883 cites W2122369380 @default.
- W4300166883 cites W2137181933 @default.
- W4300166883 cites W2139623754 @default.
- W4300166883 cites W2142656879 @default.
- W4300166883 cites W2153416566 @default.
- W4300166883 cites W2154075447 @default.
- W4300166883 cites W2155255799 @default.
- W4300166883 cites W2158117877 @default.
- W4300166883 cites W2160108273 @default.
- W4300166883 cites W2161307276 @default.
- W4300166883 cites W2170818228 @default.
- W4300166883 cites W2321885839 @default.
- W4300166883 cites W2415084001 @default.
- W4300166883 cites W2547236059 @default.
- W4300166883 cites W2743522803 @default.
- W4300166883 cites W2759239761 @default.
- W4300166883 cites W2775512209 @default.
- W4300166883 cites W2791853504 @default.
- W4300166883 cites W2792588613 @default.
- W4300166883 cites W2810350200 @default.
- W4300166883 cites W2907321904 @default.
- W4300166883 cites W2913111280 @default.
- W4300166883 cites W2914548598 @default.
- W4300166883 cites W3007794863 @default.
- W4300166883 cites W3054921167 @default.
- W4300166883 cites W3111151259 @default.
- W4300166883 cites W3123656532 @default.
- W4300166883 cites W3164692211 @default.
- W4300166883 cites W3198471559 @default.
- W4300166883 cites W3200582839 @default.
- W4300166883 cites W861789265 @default.
- W4300166883 doi "https://doi.org/10.3389/fimmu.2022.1011209" @default.
- W4300166883 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36263021" @default.
- W4300166883 hasPublicationYear "2022" @default.
- W4300166883 type Work @default.
- W4300166883 citedByCount "1" @default.
- W4300166883 countsByYear W43001668832023 @default.
- W4300166883 crossrefType "journal-article" @default.
- W4300166883 hasAuthorship W4300166883A5016158429 @default.
- W4300166883 hasAuthorship W4300166883A5016293777 @default.
- W4300166883 hasAuthorship W4300166883A5038080781 @default.
- W4300166883 hasAuthorship W4300166883A5056330567 @default.
- W4300166883 hasAuthorship W4300166883A5058424034 @default.
- W4300166883 hasAuthorship W4300166883A5078970596 @default.
- W4300166883 hasAuthorship W4300166883A5080710418 @default.
- W4300166883 hasBestOaLocation W43001668831 @default.
- W4300166883 hasConcept C139563560 @default.
- W4300166883 hasConcept C19317047 @default.
- W4300166883 hasConcept C203014093 @default.
- W4300166883 hasConcept C22222904 @default.
- W4300166883 hasConcept C2776090121 @default.
- W4300166883 hasConcept C2776156784 @default.
- W4300166883 hasConcept C2778607024 @default.
- W4300166883 hasConcept C86803240 @default.
- W4300166883 hasConcept C8891405 @default.
- W4300166883 hasConcept C95444343 @default.
- W4300166883 hasConceptScore W4300166883C139563560 @default.
- W4300166883 hasConceptScore W4300166883C19317047 @default.
- W4300166883 hasConceptScore W4300166883C203014093 @default.
- W4300166883 hasConceptScore W4300166883C22222904 @default.
- W4300166883 hasConceptScore W4300166883C2776090121 @default.
- W4300166883 hasConceptScore W4300166883C2776156784 @default.
- W4300166883 hasConceptScore W4300166883C2778607024 @default.