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- W4300188162 endingPage "361" @default.
- W4300188162 startingPage "339" @default.
- W4300188162 abstract "Background/Aims: This study aimed to characterize the exchange of fuel substrates in the splanchnic circulation in acute liver failure.Methods: Liver vein catheterization was used in 22 patients with acute liver failure after development of hepatic encephalopathy grade III-IV. Healthy controls, patients with cirrhosis and patients with acute on chronic liver disease were also studied.Results: In acute liver failure there was splanchnic removal of glucose (0.21±0.44 mmol/min), release of lactate (0.34±0.37 mmol/min), pyruvate (0.08±0.06 mmol/min) and ketone bodies (0.04±0.02 mmol/min), while extraction of amino acids and free fatty acids was insignificant. In the acute liver failure group, a normal hepatic venous oxygen saturation (0.69±0.12) and normal pyruvate/lactate ratio suggested absence of hypoxia even though the acetoacetate/β-hydroxybutyrate ratio was decreased. Only in the acute liver failure group did the measured splanchnic oxygen content difference exceed what could be accounted for even by hypothesizing complete oxidation of all extracted blood-borne fuel substrates; oxidation of endogenous substrates may be quantitatively important in this condition.Conclusion: Acute liver failure was associated with a state of accelerated glycolysis in the splanchnic region, leading to release of lactate in the absence of splanchnic hypoxia." @default.
- W4300188162 created "2022-10-03" @default.
- W4300188162 creator A5021785852 @default.
- W4300188162 creator A5089397114 @default.
- W4300188162 date "1982-07-01" @default.
- W4300188162 modified "2023-10-18" @default.
- W4300188162 title "3 Hormonal control of ketone body metabolism in the normal and diabetic state" @default.
- W4300188162 cites W111256730 @default.
- W4300188162 cites W114006166 @default.
- W4300188162 cites W118817970 @default.
- W4300188162 cites W125551675 @default.
- W4300188162 cites W1488694825 @default.
- W4300188162 cites W1501800471 @default.
- W4300188162 cites W152486275 @default.
- W4300188162 cites W1525562492 @default.
- W4300188162 cites W1532885370 @default.
- W4300188162 cites W1535112631 @default.
- W4300188162 cites W1542693186 @default.
- W4300188162 cites W1550486395 @default.
- W4300188162 cites W1554239817 @default.
- W4300188162 cites W1567007453 @default.
- W4300188162 cites W1570881500 @default.
- W4300188162 cites W1570887094 @default.
- W4300188162 cites W1577233937 @default.
- W4300188162 cites W1581705633 @default.
- W4300188162 cites W1596345646 @default.
- W4300188162 cites W1601102460 @default.
- W4300188162 cites W162162663 @default.
- W4300188162 cites W1650544568 @default.
- W4300188162 cites W175470481 @default.
- W4300188162 cites W1801184284 @default.
- W4300188162 cites W1803705701 @default.
- W4300188162 cites W1826289931 @default.
- W4300188162 cites W1845835962 @default.
- W4300188162 cites W1854155259 @default.
- W4300188162 cites W192948372 @default.
- W4300188162 cites W1938370906 @default.
- W4300188162 cites W1964653017 @default.
- W4300188162 cites W1966946242 @default.
- W4300188162 cites W1968280009 @default.
- W4300188162 cites W1969555972 @default.
- W4300188162 cites W1971012781 @default.
- W4300188162 cites W1971577453 @default.
- W4300188162 cites W1973560472 @default.
- W4300188162 cites W1975209396 @default.
- W4300188162 cites W1976380177 @default.
- W4300188162 cites W1979570442 @default.
- W4300188162 cites W1979592844 @default.
- W4300188162 cites W1980068317 @default.
- W4300188162 cites W1983883293 @default.
- W4300188162 cites W1984784775 @default.
- W4300188162 cites W1986948210 @default.
- W4300188162 cites W1987793631 @default.
- W4300188162 cites W1989420003 @default.
- W4300188162 cites W1990179580 @default.
- W4300188162 cites W1990988886 @default.
- W4300188162 cites W1994323704 @default.
- W4300188162 cites W1998639344 @default.
- W4300188162 cites W2001008916 @default.
- W4300188162 cites W2001242945 @default.
- W4300188162 cites W2003781513 @default.
- W4300188162 cites W2004728223 @default.
- W4300188162 cites W2004890167 @default.
- W4300188162 cites W2005591907 @default.
- W4300188162 cites W2006741725 @default.
- W4300188162 cites W2007063808 @default.
- W4300188162 cites W2007795347 @default.
- W4300188162 cites W2017332686 @default.
- W4300188162 cites W2020540326 @default.
- W4300188162 cites W2026053332 @default.
- W4300188162 cites W2026244382 @default.
- W4300188162 cites W2030626087 @default.
- W4300188162 cites W2035061034 @default.
- W4300188162 cites W2037438579 @default.
- W4300188162 cites W2044611878 @default.
- W4300188162 cites W2045198320 @default.
- W4300188162 cites W2045908033 @default.
- W4300188162 cites W2045981461 @default.
- W4300188162 cites W2047573371 @default.
- W4300188162 cites W2048921837 @default.
- W4300188162 cites W2049558566 @default.
- W4300188162 cites W2050112865 @default.
- W4300188162 cites W2051090017 @default.
- W4300188162 cites W2052642081 @default.
- W4300188162 cites W2057934386 @default.
- W4300188162 cites W2059186446 @default.
- W4300188162 cites W2062367511 @default.
- W4300188162 cites W2062392784 @default.
- W4300188162 cites W2064180997 @default.
- W4300188162 cites W2068272990 @default.
- W4300188162 cites W2069104225 @default.
- W4300188162 cites W2070393858 @default.
- W4300188162 cites W2071193684 @default.
- W4300188162 cites W2074422903 @default.
- W4300188162 cites W2075007247 @default.
- W4300188162 cites W2078849712 @default.
- W4300188162 cites W2080271817 @default.
- W4300188162 cites W2082961835 @default.