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• W4300231726 endingPage "3034" @default.
• W4300231726 startingPage "3026" @default.
• W4300231726 abstract "The responsiveness of spinal cord nociceptive neurons to innocuous mechanical stimuli can be increased by the release of excitatory amino acids (EAAs) and peptides attributable to an injury-induced barrage of impulses. This sensitization of spinal dorsal horn neurons can also result from administration of phorbol ester by microdialysis, presumably by direct activation of protein kinase C (PKC). This study was designed to examine the effects of central sensitization of spinothalamic tract (STT) neurons produced by intradermal injection of capsaicin on the descending inhibition driven from the periaqueductal gray (PAG) and the possible role of PKC in this process in anesthetized monkeys. Sensitization of responses of STT cells to mechanical stimuli was induced by intradermal injection of capsaicin. PAG inhibition was significantly attenuated when sensitization of responses to mechanical stimuli occurred. However, perfusion of the spinal cord with NPC15437 (a selective PKC inhibitor) by microdialysis could prevent the sensitization of the responses to mechanical stimuli and the reduction in PAG inhibition of these responses induced by capsaicin injection. Results similar to those produced by capsaicin injection were observed when a PKC activator, phorbol ester (12- O -tetradecanoylphorbol-13-acetate), was infused within the dorsal horn by microdialysis. An inactive phorbol ester (4α-phorbol 12,13-didecanoate) had no effect. These results provide evidence that the activation of PKC contributes to the development of central sensitization in dorsal horn neurons produced by chemical stimulation with capsaicin. Attenuation of the effectiveness of PAG inhibition takes place when the sensitization of dorsal horn cells develops, and PKC may play a significant role in this process." @default.
• W4300231726 created "2022-10-03" @default.
• W4300231726 creator A5049081049 @default.
• W4300231726 creator A5072010374 @default.
• W4300231726 creator A5077385691 @default.
• W4300231726 date "1996-05-01" @default.
• W4300231726 modified "2023-10-08" @default.
• W4300231726 title "Possible Role of Protein Kinase C in the Sensitization of Primate Spinothalamic Tract Neurons" @default.
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• W4300231726 doi "https://doi.org/10.1523/jneurosci.16-09-03026.1996" @default.
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