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- W4300248045 abstract "Abstract CD8 + T cells recognize antigenic peptides bound to major histocompatibility complex (MHC) class I molecules on normal antigen‐presenting cells (APC), as well as on virus‐infected cells or tumour cells (pMHC). At least two receptor types participate in recognition of these complexes: T‐cell receptor (TCR) α β heterodimers and CD8 α β molecules. The former molecules react with antigenic peptide and variable regions of MHC class I molecules, whereas the latter molecules react with constant α 3 regions of MHC class I molecules. As the avidity of both receptor‐MHC interactions is low, it is believed that TCR α β and CD8 α β heterodimers collaborate in T‐cell recognition. We have established a TCR/CD3–CD8 capture ELISA, which can measure the interaction of pMHC with CD8 α β molecules and with TCR/CD3 complexes. The major findings are: (1) TCR/CD3 complexes derived from in vitro activated T cells and captured by anti‐CD3 MoAb, do bind specific pMHC and (2) CD8 + T cells express at least three forms of CD8 α β molecules: single CD8 α β , CD3–CD8 and TCR/CD3–CD8 complexes. Only the latter complexes are associated with CD3 ζ homodimers, and the quantity of TCR/CD3–CD8 complexes relative to total CD8 α β molecules appears to increase and to be selected into sucrose‐gradient microdomains as a function of TCR α β ‐mediated T‐cell activation." @default.
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- W4300248045 date "2006-08-09" @default.
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- W4300248045 title "Interactions between CD8αβ and the TCRαβ/CD3-receptor Complex" @default.
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- W4300248045 doi "https://doi.org/10.1111/j.1365-3083.2006.01798.x" @default.
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