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- W4300259304 abstract "Using a recently developed mesoscopic theory of protein dielectrics, we have calculated the salt bridge energies, total residue electrostatic potential energies, and transfer energies into a low dielectric amyloid-like phase for 12 species and mutants of the prion protein. Salt bridges and self energies play key roles in stabilizing secondary and tertiary structural elements of the prion protein. The total electrostatic potential energy of each residue was found to be invariably stabilizing. Residues frequently found to be mutated in familial prion disease were among those with the largest electrostatic energies. The large barrier to charged group desolvation imposes regional constraints on involvement of the prion protein in an amyloid aggregate, resulting in an electrostatic amyloid recruitment profile that favours regions of sequence between alpha helix 1 and beta strand 2, the middles of helices 2 and 3, and the region N-terminal to alpha helix 1. We found that the stabilization due to salt bridges is minimal among the proteins studied for disease-susceptible human mutants of prion protein." @default.
- W4300259304 created "2022-10-03" @default.
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- W4300259304 date "2010-04-01" @default.
- W4300259304 modified "2023-10-02" @default.
- W4300259304 title "Electrostatics in the stability and misfolding of the prion protein: salt bridges, self energy, and solvationThis paper is one of a selection of papers published in this special issue entitled “Canadian Society of Biochemistry, Molecular & Cellular Biology 52nd Annual Meeting — Protein Folding: Principles and Diseases” and has undergone the Journal's usual peer review process." @default.
- W4300259304 cites W1548718817 @default.
- W4300259304 cites W1964249554 @default.
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- W4300259304 cites W1978373532 @default.
- W4300259304 cites W1987160823 @default.
- W4300259304 cites W1988296538 @default.
- W4300259304 cites W2001763373 @default.
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- W4300259304 doi "https://doi.org/10.1139/o09-180" @default.
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