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- W4300305839 abstract "Scientists at the Johns Hopkins University in Baltimore, Maryland, and in India recently reported having sequenced, For the first time ever, the complete genome of a form of HIV from India. HIV-1 subtype C is the predominant form of HIV in India and is also dominant in Africa and Southeast Asia. Study findings are based upon blood samples drawn from 6 newly infected Indian volunteers, 2 who had received contaminated transfusions and 4 clients of a STD clinic in western India. While the virus identified in these subjects has much in common with subtype C samples worldwide, the genes coding for proteins in the outer envelope of the virus vary considerably from the subtype B strains upon which most vaccines currently in international trials are being tested. HIV's outer envelope is the target of most trial antiviral vaccines to date. These findings suggest that problems will likely be encountered with any HIV vaccine based solely upon envelope proteins. In addition, 1 patient had a virus which was a mix of HIV-1 subtypes A and C. Such mosaics are the major form of HIV in Thailand and Brazil, and may have a survival advantage over single subtype strains. Research also suggests that it is more difficult to create a vaccine against HIV cross-strains." @default.
- W4300305839 created "2022-10-03" @default.
- W4300305839 date "1999-01-25" @default.
- W4300305839 modified "2023-10-18" @default.
- W4300305839 title "Sequencing of HIV from India waves a red flag for vaccine developers." @default.
- W4300305839 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12321961" @default.
- W4300305839 hasPublicationYear "1999" @default.
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