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• W4300388429 abstract "Abstract Background While the presence of SARS-CoV-2 in human breast milk is contentious, anti-SARS-CoV-2 antibodies have been consistently detected in the human breast milk. However, it is uncertain when the antibodies become present and for how long they last. Methods: This was a prospective cohort study including all consecutive pregnant women with confirmed SARS-CoV-2 infection during pregnancy, recruited at six maternity units in Spain and Hong Kong over a one-year period. Colostrum and mature milk were prospectively collected by manual expression with strict contact precautions and paired maternal blood samples were also collected. Colostrum samples were first tested with rRT-PCR-SARS-CoV-2 and skimmed acellular milk and maternal sera were tested against SARS-CoV-2 specific immunoglobulin (Ig) M, A and G reactive to receptor binding domain of SARS-CoV-2 spike protein 1 to determine the presence of immunoglobulins. Then, we examined how the presence of each immunoglobulin type in the colostrum was related to the time when infection was acquired by logistic regression analysis and how they were correlated to the immunoglobulins present in maternal serum and mature milk by Cohen’s kappa statistic. Results 187 pregnant women with confirmed SARS-CoV-2 infection during pregnancy or at delivery were recruited. No SARS-CoV-2 was found in the human breast milk. IgA and IgG were present in 129/162 and 5/163 colostrum samples and in 19/74 and 3/74 mature milk samples, respectively. IgA was the predominant immunoglobulin found in the breast milk and its levels were significantly higher in the colostrum than in the mature milk. We did not find that the presence of immunoglobulins in the colostrum was correlated to their presence in maternal serum, the severity of the disease or the time when the infection had occurred. Interpretation Since antibodies are found in the colostrum irrespective of the time of infection and SARS-CoV-2 is not detected in human breast milk, all women should be encouraged to breastfeed, undertaking contact precautions when there is active disease. Funding This study was conducted thanks to scholarships granted by the Spanish Ministry of Health (Instituto de Salud Carlos III: COV20/00188) and by iMaterna foundation (www.imaterna.org). PerkinElmer® provided the laboratory reagents and Synlab Diagnósticos Globales (Madrid, Spain) provided human resources to conduct the analyses performed in Madrid." @default.
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• W4300388429 date "2022-05-24" @default.
• W4300388429 modified "2023-10-16" @default.
• W4300388429 title "Anti-SARS-CoV-2-specific antibodies in human breast milk following SARS-CoV-2 infection during pregnancy: a prospective cohort study" @default.
• W4300388429 doi "https://doi.org/10.21203/rs.3.rs-1669425/v1" @default.
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