Matches in SemOpenAlex for { <https://semopenalex.org/work/W4300414722> ?p ?o ?g. }
Showing items 1 to 78 of
78
with 100 items per page.
- W4300414722 abstract "Simplified drug-resistant tuberculosis (DR-TB) treatment outcome definitions, mostly centred around receipt of treatment and sputum culture status at 6 months after treatment initiation, have been proposed, but have not been widely evaluated in resource-limited settings.To compare DR-TB treatment outcomes, as defined by the World Health Organization (WHO) at the time of treatment, with simplified definitions.We performed retrospective folder reviews of a cohort of 246 South African DR-TB patients, most of whom developed second-line drug resistance. Sequential treatment outcomes were assigned retrospectively using both simplified Tuberculosis Network European Trials Group (TBNET)-based and 2013 WHO-based definitions.Of 246 patients, 40% were HIV-positive, and 88% developed second-line drug resistance. Patients were observed for a median of 38 (interquartile range 24 - 63) months from DR-TB treatment initiation. Using WHO-based definitions, 93% of patients had >1 sequential outcome, whereas with simplified definitions, 25% of patients had >1 outcome. Fewer outcomes of cure (3% v. 9%) and more outcomes of treatment failure (42% v. 22%) were assigned using simplified definitions.Simplified outcome definitions applied to real-world patients with long, often complex treatment histories resulted in underestimating cures and overestimating treatment failures compared with WHO-based definitions. Simplified definitions may identify more individuals at higher risk for treatment failure than WHO-based definitions, but without consistent programmatic follow-up it may be difficult to distinguish cure, failure and loss to follow-up." @default.
- W4300414722 created "2022-10-03" @default.
- W4300414722 creator A5013788849 @default.
- W4300414722 creator A5033424301 @default.
- W4300414722 creator A5040749328 @default.
- W4300414722 creator A5056139536 @default.
- W4300414722 date "2022-01-01" @default.
- W4300414722 modified "2023-09-30" @default.
- W4300414722 title "Comparison of treatment outcome definitions in drug-resistant tuberculosis patients with high incidence of acquired second-line drug resistance." @default.
- W4300414722 cites W2093274439 @default.
- W4300414722 cites W2146416369 @default.
- W4300414722 cites W2340472493 @default.
- W4300414722 cites W2519235272 @default.
- W4300414722 cites W2945227688 @default.
- W4300414722 cites W3165874521 @default.
- W4300414722 cites W4282922166 @default.
- W4300414722 doi "https://doi.org/10.7196/ajtccm.2022.v28i2.177" @default.
- W4300414722 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35991341" @default.
- W4300414722 hasPublicationYear "2022" @default.
- W4300414722 type Work @default.
- W4300414722 citedByCount "0" @default.
- W4300414722 crossrefType "journal-article" @default.
- W4300414722 hasAuthorship W4300414722A5013788849 @default.
- W4300414722 hasAuthorship W4300414722A5033424301 @default.
- W4300414722 hasAuthorship W4300414722A5040749328 @default.
- W4300414722 hasAuthorship W4300414722A5056139536 @default.
- W4300414722 hasConcept C114851261 @default.
- W4300414722 hasConcept C119060515 @default.
- W4300414722 hasConcept C126322002 @default.
- W4300414722 hasConcept C141071460 @default.
- W4300414722 hasConcept C142724271 @default.
- W4300414722 hasConcept C167135981 @default.
- W4300414722 hasConcept C177713679 @default.
- W4300414722 hasConcept C2776301714 @default.
- W4300414722 hasConcept C2777025531 @default.
- W4300414722 hasConcept C2777107064 @default.
- W4300414722 hasConcept C2777975735 @default.
- W4300414722 hasConcept C2781069245 @default.
- W4300414722 hasConcept C3019056677 @default.
- W4300414722 hasConcept C3020294253 @default.
- W4300414722 hasConcept C71924100 @default.
- W4300414722 hasConcept C86803240 @default.
- W4300414722 hasConcept C89423630 @default.
- W4300414722 hasConceptScore W4300414722C114851261 @default.
- W4300414722 hasConceptScore W4300414722C119060515 @default.
- W4300414722 hasConceptScore W4300414722C126322002 @default.
- W4300414722 hasConceptScore W4300414722C141071460 @default.
- W4300414722 hasConceptScore W4300414722C142724271 @default.
- W4300414722 hasConceptScore W4300414722C167135981 @default.
- W4300414722 hasConceptScore W4300414722C177713679 @default.
- W4300414722 hasConceptScore W4300414722C2776301714 @default.
- W4300414722 hasConceptScore W4300414722C2777025531 @default.
- W4300414722 hasConceptScore W4300414722C2777107064 @default.
- W4300414722 hasConceptScore W4300414722C2777975735 @default.
- W4300414722 hasConceptScore W4300414722C2781069245 @default.
- W4300414722 hasConceptScore W4300414722C3019056677 @default.
- W4300414722 hasConceptScore W4300414722C3020294253 @default.
- W4300414722 hasConceptScore W4300414722C71924100 @default.
- W4300414722 hasConceptScore W4300414722C86803240 @default.
- W4300414722 hasConceptScore W4300414722C89423630 @default.
- W4300414722 hasIssue "2" @default.
- W4300414722 hasLocation W43004147221 @default.
- W4300414722 hasOpenAccess W4300414722 @default.
- W4300414722 hasPrimaryLocation W43004147221 @default.
- W4300414722 hasRelatedWork W1817919821 @default.
- W4300414722 hasRelatedWork W1971853437 @default.
- W4300414722 hasRelatedWork W1994412089 @default.
- W4300414722 hasRelatedWork W2013013057 @default.
- W4300414722 hasRelatedWork W2736669723 @default.
- W4300414722 hasRelatedWork W2895817599 @default.
- W4300414722 hasRelatedWork W2906875615 @default.
- W4300414722 hasRelatedWork W4283661591 @default.
- W4300414722 hasRelatedWork W4293728936 @default.
- W4300414722 hasRelatedWork W579183227 @default.
- W4300414722 hasVolume "28" @default.
- W4300414722 isParatext "false" @default.
- W4300414722 isRetracted "false" @default.
- W4300414722 workType "article" @default.