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- W4300450010 abstract "Physicians and researchers received a stronger warning from Bristol-Myers Squibb (BMS) this week about the risk of pancreatitis in patients taking ddI (Videx). The risk is higher if they are also taking d4T, with or without Hydroxyurea (Hydrea). There have been four deaths in recent clinical trials. Each of the four had CD4 counts greater than 500, viral loads below 200 copies, and were taking d4T. Two of the four were also enrolled in a study which included ddI, d4T, and Hydroxyurea, and three had known risk factors for pancreatitis. The new warning follows an October 27 letter from the FDA to BMS after an investigation found the drug company failed to disclose important safety information, and was promoting hydroxyurea for unapproved uses. The text of the warning letter, as well as a web site address for the full text of the FDA warning, is included." @default.
- W4300450010 created "2022-10-03" @default.
- W4300450010 date "1999-11-19" @default.
- W4300450010 modified "2023-09-29" @default.
- W4300450010 title "ddI, d4T, Hydroxyurea: new pancreatitis warning." @default.
- W4300450010 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11367125" @default.
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