Matches in SemOpenAlex for { <https://semopenalex.org/work/W4300478086> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W4300478086 endingPage "2087" @default.
- W4300478086 startingPage "2083" @default.
- W4300478086 abstract "Abstract We have determined serum activity and kinetic constants of angiotensin I-converting enzyme (ACE), parallel to an insertion/deletion (I/D) polymorphism in its gene, in French centenarians and controls 20–70 years of age because this enzyme could have an impact on cardiovascular risk, and thus on longevity. Both the ACE D allele and ACE D/D genotype were more frequent in centenarians in comparison with controls, without sex-related differences nor significant correlation with a cardiovascular pathology. In centenarians, I/D polymorphism was correlated with circulating ACE activity (D/D genotype, 89.0 ± 36.8 U/L; I/D genotype, 63.5 ± 26.0 U/L; and I/I genotype, 55.1 ± 39.4 U/L). The Michaelis constants for two substrates were identical whatever the genotype and were not different between centenarians and controls, i.e., 0.30 ± 0.03 mmol/L for furylacryloyl-phenylalanyl-glycyl-glycine and 1.35 ± 0.05 mmol/L for hippuryl-histidyl-leucine; for the latter, the optimal pH and activating concentration of chloride did not depend on I/D polymorphism. The maximal velocities with both substrates reflected the distribution of serum ACE activity as a function of the genotypes, in centenarians and in controls. In conclusion, plasma ACE activity is subject to a similar genotypic influence in centenarians as in adults 20–70 years of age; however, ACE itself appears to be functionally similar for each genotype. Furthermore, the D allele as well as the higher serum ACE activities associated with the D/D genotype cannot discriminate individuals at high risk for cardiovascular diseases, major causes of mortality before the age of 100 years." @default.
- W4300478086 created "2022-10-03" @default.
- W4300478086 creator A5028459795 @default.
- W4300478086 creator A5032770887 @default.
- W4300478086 creator A5055138617 @default.
- W4300478086 creator A5055266405 @default.
- W4300478086 creator A5074167536 @default.
- W4300478086 creator A5085493727 @default.
- W4300478086 date "1998-10-01" @default.
- W4300478086 modified "2023-10-18" @default.
- W4300478086 title "Plasma concentration, kinetic constants, and gene polymorphism of angiotensin I-converting enzyme in centenarians" @default.
- W4300478086 cites W1906352940 @default.
- W4300478086 cites W1972792954 @default.
- W4300478086 cites W1981681688 @default.
- W4300478086 cites W2027232842 @default.
- W4300478086 cites W2043600435 @default.
- W4300478086 cites W2069863984 @default.
- W4300478086 cites W2072262664 @default.
- W4300478086 cites W2097532633 @default.
- W4300478086 doi "https://doi.org/10.1093/clinchem/44.10.2083" @default.
- W4300478086 hasPublicationYear "1998" @default.
- W4300478086 type Work @default.
- W4300478086 citedByCount "41" @default.
- W4300478086 countsByYear W43004780862012 @default.
- W4300478086 countsByYear W43004780862013 @default.
- W4300478086 countsByYear W43004780862014 @default.
- W4300478086 countsByYear W43004780862015 @default.
- W4300478086 countsByYear W43004780862016 @default.
- W4300478086 countsByYear W43004780862018 @default.
- W4300478086 countsByYear W43004780862019 @default.
- W4300478086 countsByYear W43004780862021 @default.
- W4300478086 countsByYear W43004780862022 @default.
- W4300478086 countsByYear W43004780862023 @default.
- W4300478086 crossrefType "journal-article" @default.
- W4300478086 hasAuthorship W4300478086A5028459795 @default.
- W4300478086 hasAuthorship W4300478086A5032770887 @default.
- W4300478086 hasAuthorship W4300478086A5055138617 @default.
- W4300478086 hasAuthorship W4300478086A5055266405 @default.
- W4300478086 hasAuthorship W4300478086A5074167536 @default.
- W4300478086 hasAuthorship W4300478086A5085493727 @default.
- W4300478086 hasBestOaLocation W43004780861 @default.
- W4300478086 hasConcept C104317684 @default.
- W4300478086 hasConcept C126322002 @default.
- W4300478086 hasConcept C134018914 @default.
- W4300478086 hasConcept C135763542 @default.
- W4300478086 hasConcept C149737253 @default.
- W4300478086 hasConcept C180754005 @default.
- W4300478086 hasConcept C181199279 @default.
- W4300478086 hasConcept C185592680 @default.
- W4300478086 hasConcept C27016395 @default.
- W4300478086 hasConcept C54355233 @default.
- W4300478086 hasConcept C55493867 @default.
- W4300478086 hasConcept C71924100 @default.
- W4300478086 hasConcept C84393581 @default.
- W4300478086 hasConcept C86803240 @default.
- W4300478086 hasConceptScore W4300478086C104317684 @default.
- W4300478086 hasConceptScore W4300478086C126322002 @default.
- W4300478086 hasConceptScore W4300478086C134018914 @default.
- W4300478086 hasConceptScore W4300478086C135763542 @default.
- W4300478086 hasConceptScore W4300478086C149737253 @default.
- W4300478086 hasConceptScore W4300478086C180754005 @default.
- W4300478086 hasConceptScore W4300478086C181199279 @default.
- W4300478086 hasConceptScore W4300478086C185592680 @default.
- W4300478086 hasConceptScore W4300478086C27016395 @default.
- W4300478086 hasConceptScore W4300478086C54355233 @default.
- W4300478086 hasConceptScore W4300478086C55493867 @default.
- W4300478086 hasConceptScore W4300478086C71924100 @default.
- W4300478086 hasConceptScore W4300478086C84393581 @default.
- W4300478086 hasConceptScore W4300478086C86803240 @default.
- W4300478086 hasIssue "10" @default.
- W4300478086 hasLocation W43004780861 @default.
- W4300478086 hasOpenAccess W4300478086 @default.
- W4300478086 hasPrimaryLocation W43004780861 @default.
- W4300478086 hasRelatedWork W2023055758 @default.
- W4300478086 hasRelatedWork W2134373856 @default.
- W4300478086 hasRelatedWork W2261335360 @default.
- W4300478086 hasRelatedWork W2347271704 @default.
- W4300478086 hasRelatedWork W2350604900 @default.
- W4300478086 hasRelatedWork W2353519697 @default.
- W4300478086 hasRelatedWork W2359510619 @default.
- W4300478086 hasRelatedWork W2385665726 @default.
- W4300478086 hasRelatedWork W2391157579 @default.
- W4300478086 hasRelatedWork W3029453589 @default.
- W4300478086 hasVolume "44" @default.
- W4300478086 isParatext "false" @default.
- W4300478086 isRetracted "false" @default.
- W4300478086 workType "article" @default.