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• W4300482726 endingPage "31" @default.
• W4300482726 startingPage "1" @default.
• W4300482726 abstract "The human genome is a large and complex storehouse of information that is meticulously propagated and deciphered by the macromolecular assemblies of gene regulatory proteins and RNAs. An intricate network of feed-forward and feedback interactions among these entities ensures the precise levels of gene expression in any cell type in a given context. Such macromolecular interactions involve simple diffusion, synergistic interactions, phase separation (in the nucleus), and kinetic regulations. Molecular biology, the subdiscipline that studies the process of gene expression, has also shown phenomenal growth since the discovery of the DNA structure in 1953. The title word “Gene expression” yielded 95,691 entries in PubMed of which 7186 were reviewed articles as of January 31, 2022. Almost all other disciplines of biology viz., biochemistry, structural biology, genetics, epigenetics, developmental biology, proteomics, transcriptomics, and bioinformatics have significantly contributed toward the accumulation of such a large volume of information. Thus, although it would be a gargantuan effort to summarize such an ocean of information in a single review, I have only summarized major aspects of gene expression viz., the structure of core promoters, the RNA polymerases, and transcription factors that performs the synthesis of pre-mRNA, post-transcriptional processing of the pre-mRNA, small regulatory RNAs, and epigenetic regulation. Also, for further information for the readers, I have cited the recent reviews by eminent researchers for each of the topics that I have covered, albeit except citing the original pioneering discoveries. I hope this review will give the readers a platform to comprehend the essence of the excitements in the field as provided by the other authors of this book on post-transcriptional gene regulation in the context of various human diseases" @default.
• W4300482726 created "2022-10-03" @default.
• W4300482726 creator A5023408129 @default.
• W4300482726 date "2022-01-01" @default.
• W4300482726 modified "2023-09-26" @default.
• W4300482726 title "Regulation of gene expression in mammals" @default.
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