Matches in SemOpenAlex for { <https://semopenalex.org/work/W4300484766> ?p ?o ?g. }
- W4300484766 abstract "Abstract Background: Immune-related genes have been confirmed to be related to tumor development and anti-tumor immune response. Therefore, immune-related genes are potential candidate for predicting prognosis and immunotherapy response. We aimed to explore the relationship between immune-related genes and the prognosis, tumor microenvironment and response to immunotherapy in HCC. Methods: The immune-related gene-based prognostic index (IRGPI) is constructed by 4 hub genes that are most closely related to prognosis among 1.811 immune related genes. We then sequentially compared the differences in clinical characteristics, driver gene mutations, immune microenvironment and immunotherapy between the two groups of IRGPI. Finally, multiplex immunofluorescence staining was used to assess the abundance of infiltrating CD8 + T cells in tumor microenvironment between different subgroups. Results: IRGPI-high significantly related to higher disease progression and shorter survival time. IRGPI is accompanied by a higher TMB and frequency of driver gene mutations that predicts worse prognosis. In tumor microenvironment, the number and activity of tumor-infiltrating immune cells in the IRGPI-low group was significantly greater than that of the IRGPI-high. TIDE and three immunotherapy datasets showed that patients in the IRGPI-low group are more in an immune dysfunction state and respond well to ICIs. Immunostaining on the HCC cohort further confirmed that CD8 + T cells were more abundant in IRGPI-low group, while the tumor microenvironment of IRGPI-high group presents a scene of immune desert, which corresponds to our results and partly explains why IRGPI-high group cannot respond well to ICIs. Conclusions: IRGPI was created based on the immune-related genes in HCC. The novel prognostic model can predict prognosis and response to ICIs in HCC patients." @default.
- W4300484766 created "2022-10-03" @default.
- W4300484766 creator A5001181407 @default.
- W4300484766 creator A5001774854 @default.
- W4300484766 creator A5004133329 @default.
- W4300484766 creator A5015467895 @default.
- W4300484766 creator A5039784240 @default.
- W4300484766 creator A5056605505 @default.
- W4300484766 creator A5087057818 @default.
- W4300484766 date "2022-10-03" @default.
- W4300484766 modified "2023-10-16" @default.
- W4300484766 title "The immune-related gene-based prognostic index predicts the prognosis and effect of immune checkpoint inhibitors in hepatocellular carcinoma" @default.
- W4300484766 cites W1498931318 @default.
- W4300484766 cites W1810028515 @default.
- W4300484766 cites W1910012553 @default.
- W4300484766 cites W1966327575 @default.
- W4300484766 cites W1985987855 @default.
- W4300484766 cites W2025738474 @default.
- W4300484766 cites W2028433016 @default.
- W4300484766 cites W2042699075 @default.
- W4300484766 cites W2104885590 @default.
- W4300484766 cites W2130430382 @default.
- W4300484766 cites W2146512944 @default.
- W4300484766 cites W2194546364 @default.
- W4300484766 cites W2293494611 @default.
- W4300484766 cites W2506616866 @default.
- W4300484766 cites W2737082469 @default.
- W4300484766 cites W2747107882 @default.
- W4300484766 cites W2763700772 @default.
- W4300484766 cites W2787553551 @default.
- W4300484766 cites W2886498337 @default.
- W4300484766 cites W2888408613 @default.
- W4300484766 cites W2896872272 @default.
- W4300484766 cites W2897422388 @default.
- W4300484766 cites W2900082702 @default.
- W4300484766 cites W2907190362 @default.
- W4300484766 cites W2914311347 @default.
- W4300484766 cites W2976744492 @default.
- W4300484766 cites W2977528366 @default.
- W4300484766 cites W2990602950 @default.
- W4300484766 cites W2999417355 @default.
- W4300484766 cites W3010504173 @default.
- W4300484766 cites W3025022288 @default.
- W4300484766 cites W3037237663 @default.
- W4300484766 cites W3045387409 @default.
- W4300484766 cites W3073964112 @default.
- W4300484766 cites W3091399767 @default.
- W4300484766 cites W3094602125 @default.
- W4300484766 cites W3097480917 @default.
- W4300484766 cites W3110578922 @default.
- W4300484766 cites W3118711697 @default.
- W4300484766 cites W3205112366 @default.
- W4300484766 cites W3207388729 @default.
- W4300484766 cites W3211603851 @default.
- W4300484766 cites W3215943325 @default.
- W4300484766 cites W4200037072 @default.
- W4300484766 cites W4200279112 @default.
- W4300484766 cites W4294541781 @default.
- W4300484766 doi "https://doi.org/10.21203/rs.3.rs-2092544/v1" @default.
- W4300484766 hasPublicationYear "2022" @default.
- W4300484766 type Work @default.
- W4300484766 citedByCount "0" @default.
- W4300484766 crossrefType "posted-content" @default.
- W4300484766 hasAuthorship W4300484766A5001181407 @default.
- W4300484766 hasAuthorship W4300484766A5001774854 @default.
- W4300484766 hasAuthorship W4300484766A5004133329 @default.
- W4300484766 hasAuthorship W4300484766A5015467895 @default.
- W4300484766 hasAuthorship W4300484766A5039784240 @default.
- W4300484766 hasAuthorship W4300484766A5056605505 @default.
- W4300484766 hasAuthorship W4300484766A5087057818 @default.
- W4300484766 hasBestOaLocation W43004847661 @default.
- W4300484766 hasConcept C143998085 @default.
- W4300484766 hasConcept C167672396 @default.
- W4300484766 hasConcept C203014093 @default.
- W4300484766 hasConcept C2776107976 @default.
- W4300484766 hasConcept C2777701055 @default.
- W4300484766 hasConcept C2778019345 @default.
- W4300484766 hasConcept C502942594 @default.
- W4300484766 hasConcept C71924100 @default.
- W4300484766 hasConcept C86803240 @default.
- W4300484766 hasConcept C8891405 @default.
- W4300484766 hasConceptScore W4300484766C143998085 @default.
- W4300484766 hasConceptScore W4300484766C167672396 @default.
- W4300484766 hasConceptScore W4300484766C203014093 @default.
- W4300484766 hasConceptScore W4300484766C2776107976 @default.
- W4300484766 hasConceptScore W4300484766C2777701055 @default.
- W4300484766 hasConceptScore W4300484766C2778019345 @default.
- W4300484766 hasConceptScore W4300484766C502942594 @default.
- W4300484766 hasConceptScore W4300484766C71924100 @default.
- W4300484766 hasConceptScore W4300484766C86803240 @default.
- W4300484766 hasConceptScore W4300484766C8891405 @default.
- W4300484766 hasLocation W43004847661 @default.
- W4300484766 hasOpenAccess W4300484766 @default.
- W4300484766 hasPrimaryLocation W43004847661 @default.
- W4300484766 hasRelatedWork W2355632798 @default.
- W4300484766 hasRelatedWork W2904909612 @default.
- W4300484766 hasRelatedWork W3025154575 @default.
- W4300484766 hasRelatedWork W3028822667 @default.
- W4300484766 hasRelatedWork W3108853735 @default.
- W4300484766 hasRelatedWork W3125366473 @default.