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- W4300522712 abstract "The mammalian host has evolved innate immune strategies to detect and respond to rapidly to diverse group of microorganisms. Microbial recognition is achieved by pattern-recognition receptors (PRRs) such as toll-like receptors (TLRs) and Nod-like receptor (NLRs). PRRs detect pathogen-associated molecular patterns (PAMPs) and activate downstream signalling pathways. NLRs have been proposed thal these cytosolic proteins regulate the cysteine protease caspase-1 within a multiprotein complex known as the inflammasome. Activation of caspase-1 leads to the cleavage and activation of proinflammatory cytokines such as interleukin-1β (lL-1β) and IL-18." @default.
- W4300522712 created "2022-10-03" @default.
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- W4300522712 date "2009-06-01" @default.
- W4300522712 modified "2023-09-26" @default.
- W4300522712 title "Pattern-recognition receptors and recognition of pathogens" @default.
- W4300522712 doi "https://doi.org/10.22730/jmls.2009.6.3.148" @default.
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