Matches in SemOpenAlex for { <https://semopenalex.org/work/W4300594329> ?p ?o ?g. }
- W4300594329 endingPage "2201661" @default.
- W4300594329 startingPage "2201661" @default.
- W4300594329 abstract "The bone immune microenvironment (BIM) regulates bone regeneration and affects the prognosis of fractures. However, there is currently no effective strategy that can precisely modulate macrophage polarization to improve BIM for bone regeneration. Herein, a hybridized biphasic bionic periosteum, inspired by the BIM and functional structure of the natural periosteum, is presented. The gel phase is composed of genipin-crosslinked carboxymethyl chitosan and collagen self-assembled hybrid hydrogels, which act as the “dam” to intercept IL-4 released during the initial burst from the bionic periosteum fiber phase, thus maintaining the moderate inflammatory response of M1 macrophages for mesenchymal stem cell recruitment and vascular sprouting at the acute fracture. With the degradation of the gel phase, released IL-4 cooperates with collagen to promote the polarization towards M2 macrophages, which reconfigure the local microenvironment by secreting PDGF-BB and BMP-2 to improve vascular maturation and osteogenesis twofold. In rat cranial defect models, the controlled regulation of the BIM is validated with the temporal transition of the inflammatory/anti-inflammatory process to achieve faster and better bone defect repair. This strategy provides a drug delivery system that constructs a coordinated BIM, so as to break through the predicament of the contradiction between immune response and bone tissue regeneration." @default.
- W4300594329 created "2022-10-03" @default.
- W4300594329 creator A5010848590 @default.
- W4300594329 creator A5017452406 @default.
- W4300594329 creator A5018271028 @default.
- W4300594329 creator A5024900488 @default.
- W4300594329 creator A5030989403 @default.
- W4300594329 creator A5044748987 @default.
- W4300594329 creator A5050848238 @default.
- W4300594329 creator A5072167724 @default.
- W4300594329 creator A5084580997 @default.
- W4300594329 creator A5090266617 @default.
- W4300594329 date "2022-10-14" @default.
- W4300594329 modified "2023-10-15" @default.
- W4300594329 title "Spatiotemporal Regulation of the Bone Immune Microenvironment via Dam‐Like Biphasic Bionic Periosteum for Bone Regeneration" @default.
- W4300594329 cites W1779029612 @default.
- W4300594329 cites W2000620469 @default.
- W4300594329 cites W2012173663 @default.
- W4300594329 cites W2020545615 @default.
- W4300594329 cites W2030696265 @default.
- W4300594329 cites W2085701716 @default.
- W4300594329 cites W2090502184 @default.
- W4300594329 cites W2128839536 @default.
- W4300594329 cites W2194806179 @default.
- W4300594329 cites W2291522985 @default.
- W4300594329 cites W2330308886 @default.
- W4300594329 cites W2517194701 @default.
- W4300594329 cites W2530382426 @default.
- W4300594329 cites W2539107597 @default.
- W4300594329 cites W2594692067 @default.
- W4300594329 cites W2602339215 @default.
- W4300594329 cites W2606271937 @default.
- W4300594329 cites W2606712735 @default.
- W4300594329 cites W2663210070 @default.
- W4300594329 cites W2736496985 @default.
- W4300594329 cites W2753423724 @default.
- W4300594329 cites W2782456302 @default.
- W4300594329 cites W2803073527 @default.
- W4300594329 cites W2859280788 @default.
- W4300594329 cites W2884099436 @default.
- W4300594329 cites W2898237260 @default.
- W4300594329 cites W2899477607 @default.
- W4300594329 cites W2900606149 @default.
- W4300594329 cites W2902676402 @default.
- W4300594329 cites W2919078487 @default.
- W4300594329 cites W2942530347 @default.
- W4300594329 cites W2945786100 @default.
- W4300594329 cites W2947325783 @default.
- W4300594329 cites W2981164203 @default.
- W4300594329 cites W2991168619 @default.
- W4300594329 cites W3002553809 @default.
- W4300594329 cites W3028402601 @default.
- W4300594329 cites W3030550095 @default.
- W4300594329 cites W3082383016 @default.
- W4300594329 cites W3084404495 @default.
- W4300594329 cites W3089411916 @default.
- W4300594329 cites W3106644905 @default.
- W4300594329 cites W3109748080 @default.
- W4300594329 cites W3116712409 @default.
- W4300594329 cites W3121454239 @default.
- W4300594329 cites W3133267105 @default.
- W4300594329 cites W3133698054 @default.
- W4300594329 cites W3138537790 @default.
- W4300594329 cites W3158121826 @default.
- W4300594329 cites W3161474660 @default.
- W4300594329 cites W3164200628 @default.
- W4300594329 cites W3165498318 @default.
- W4300594329 cites W3166345092 @default.
- W4300594329 cites W3183317072 @default.
- W4300594329 cites W3185737417 @default.
- W4300594329 cites W3187950110 @default.
- W4300594329 cites W3188362390 @default.
- W4300594329 cites W3200264717 @default.
- W4300594329 cites W3207389228 @default.
- W4300594329 cites W3213172227 @default.
- W4300594329 cites W4205274827 @default.
- W4300594329 cites W4205349987 @default.
- W4300594329 cites W4213365620 @default.
- W4300594329 cites W4220755116 @default.
- W4300594329 cites W4220874982 @default.
- W4300594329 cites W4221052788 @default.
- W4300594329 cites W4281559425 @default.
- W4300594329 cites W4285107559 @default.
- W4300594329 cites W4285605196 @default.
- W4300594329 cites W4291155772 @default.
- W4300594329 cites W4295106176 @default.
- W4300594329 doi "https://doi.org/10.1002/adhm.202201661" @default.
- W4300594329 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36189833" @default.
- W4300594329 hasPublicationYear "2022" @default.
- W4300594329 type Work @default.
- W4300594329 citedByCount "4" @default.
- W4300594329 countsByYear W43005943292023 @default.
- W4300594329 crossrefType "journal-article" @default.
- W4300594329 hasAuthorship W4300594329A5010848590 @default.
- W4300594329 hasAuthorship W4300594329A5017452406 @default.
- W4300594329 hasAuthorship W4300594329A5018271028 @default.
- W4300594329 hasAuthorship W4300594329A5024900488 @default.
- W4300594329 hasAuthorship W4300594329A5030989403 @default.