FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4300594562> ?p ?o ?g. }

• W4300594562 abstract "Bacterial growth is remarkably robust to environmental fluctuations, yet the mechanisms of growth-rate homeostasis are poorly understood. Here, we combine theory and experiment to infer mechanisms by which Escherichia coli adapts its growth rate in response to changes in osmolarity, a fundamental physicochemical property of the environment. The central tenet of our theoretical model is that cell-envelope expansion is only sensitive to local information, such as enzyme concentrations, cell-envelope curvature, and mechanical strain in the envelope. We constrained this model with quantitative measurements of the dynamics of E. coli elongation rate and cell width after hyperosmotic shock. Our analysis demonstrated that adaptive cell-envelope softening is a key process underlying growth-rate homeostasis. Furthermore, our model correctly predicted that softening does not occur above a critical hyperosmotic shock magnitude and precisely recapitulated the elongation-rate dynamics in response to shocks with magnitude larger than this threshold. Finally, we found that, to coordinately achieve growth-rate and cell-width homeostasis, cells employ direct feedback between cell-envelope curvature and envelope expansion. In sum, our analysis points to cellular mechanisms of bacterial growth-rate homeostasis and provides a practical theoretical framework for understanding this process." @default.
• W4300594562 created "2022-10-03" @default.
• W4300594562 creator A5010295526 @default.
• W4300594562 creator A5012999469 @default.
• W4300594562 creator A5018353444 @default.
• W4300594562 creator A5052019253 @default.
• W4300594562 creator A5081234972 @default.
• W4300594562 date "2022-10-03" @default.
• W4300594562 modified "2023-10-02" @default.
• W4300594562 title "Feedback linking cell envelope stiffness, curvature, and synthesis enables robust rod-shaped bacterial growth" @default.
• W4300594562 cites W1590222219 @default.
• W4300594562 cites W1964791688 @default.
• W4300594562 cites W1968723178 @default.
• W4300594562 cites W1977568111 @default.
• W4300594562 cites W1996666978 @default.
• W4300594562 cites W2014245367 @default.
• W4300594562 cites W2021312397 @default.
• W4300594562 cites W2024167557 @default.
• W4300594562 cites W2035278444 @default.
• W4300594562 cites W2054848637 @default.
• W4300594562 cites W2065151627 @default.
• W4300594562 cites W2068179698 @default.
• W4300594562 cites W2084403652 @default.
• W4300594562 cites W2105234539 @default.
• W4300594562 cites W2115069651 @default.
• W4300594562 cites W2119711877 @default.
• W4300594562 cites W2124480752 @default.
• W4300594562 cites W2129530757 @default.
• W4300594562 cites W2153979160 @default.
• W4300594562 cites W2158232793 @default.
• W4300594562 cites W2198594725 @default.
• W4300594562 cites W2414953140 @default.
• W4300594562 cites W2418012704 @default.
• W4300594562 cites W2739289182 @default.
• W4300594562 cites W2748521462 @default.
• W4300594562 cites W2766359776 @default.
• W4300594562 cites W2788000426 @default.
• W4300594562 cites W2791488513 @default.
• W4300594562 cites W2794903445 @default.
• W4300594562 cites W2806650211 @default.
• W4300594562 cites W2822066044 @default.
• W4300594562 cites W2884934298 @default.
• W4300594562 cites W2914657464 @default.
• W4300594562 cites W3011291274 @default.
• W4300594562 cites W3098120881 @default.
• W4300594562 cites W3150035693 @default.
• W4300594562 cites W3175556548 @default.
• W4300594562 cites W4212880641 @default.
• W4300594562 cites W4224135569 @default.
• W4300594562 cites W4300594562 @default.
• W4300594562 doi "https://doi.org/10.1073/pnas.2200728119" @default.
• W4300594562 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36191183" @default.
• W4300594562 hasPublicationYear "2022" @default.
• W4300594562 type Work @default.
• W4300594562 citedByCount "6" @default.
• W4300594562 countsByYear W43005945622022 @default.
• W4300594562 countsByYear W43005945622023 @default.
• W4300594562 crossrefType "journal-article" @default.
• W4300594562 hasAuthorship W4300594562A5010295526 @default.
• W4300594562 hasAuthorship W4300594562A5012999469 @default.
• W4300594562 hasAuthorship W4300594562A5018353444 @default.
• W4300594562 hasAuthorship W4300594562A5052019253 @default.
• W4300594562 hasAuthorship W4300594562A5081234972 @default.
• W4300594562 hasBestOaLocation W43005945621 @default.
• W4300594562 hasConcept C104317684 @default.
• W4300594562 hasConcept C112950240 @default.
• W4300594562 hasConcept C121332964 @default.
• W4300594562 hasConcept C12554922 @default.
• W4300594562 hasConcept C126322002 @default.
• W4300594562 hasConcept C129900496 @default.
• W4300594562 hasConcept C185592680 @default.
• W4300594562 hasConcept C186060115 @default.
• W4300594562 hasConcept C191897082 @default.
• W4300594562 hasConcept C192562407 @default.
• W4300594562 hasConcept C195065555 @default.
• W4300594562 hasConcept C2524010 @default.
• W4300594562 hasConcept C2778312390 @default.
• W4300594562 hasConcept C2781300812 @default.
• W4300594562 hasConcept C33923547 @default.
• W4300594562 hasConcept C33947775 @default.
• W4300594562 hasConcept C41008148 @default.
• W4300594562 hasConcept C46371251 @default.
• W4300594562 hasConcept C547475151 @default.
• W4300594562 hasConcept C554190296 @default.
• W4300594562 hasConcept C55493867 @default.
• W4300594562 hasConcept C57879066 @default.
• W4300594562 hasConcept C62112901 @default.
• W4300594562 hasConcept C63645605 @default.
• W4300594562 hasConcept C65155139 @default.
• W4300594562 hasConcept C71924100 @default.
• W4300594562 hasConcept C76155785 @default.
• W4300594562 hasConcept C86803240 @default.
• W4300594562 hasConcept C95444343 @default.
• W4300594562 hasConceptScore W4300594562C104317684 @default.
• W4300594562 hasConceptScore W4300594562C112950240 @default.
• W4300594562 hasConceptScore W4300594562C121332964 @default.
• W4300594562 hasConceptScore W4300594562C12554922 @default.
• W4300594562 hasConceptScore W4300594562C126322002 @default.
• W4300594562 hasConceptScore W4300594562C129900496 @default.
• W4300594562 hasConceptScore W4300594562C185592680 @default.

• next