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- W4300603118 abstract "Lonicerae japonicae Flos (LF) is a kind of healthcare food with hepatoprotective function. This study was designed to explore the spectrum-effect relationships between UPLC fingerprints and the hepatoprotective effects of LF. Fingerprints of ten batches of LF were established by UPLC-PDA. The inhibitory levels of AST and ALT were used as pharmacological indexes, and secoxyloganin, isochlorogenic acid A and isochlorogenic acid C were screened as hepatoprotective active compounds by grey relational analysis (GRA) and partial least squares regression analysis (PLSR). Caspase-3 was obtained by network pharmacology as a key target of hepatoprotective active compounds. Molecular docking is used to explore the interaction between small molecules and proteins. This work provided a general model of the combination of UPLC-PDA and hepatoprotective effect to study the spectrum-effect relationship of LF, which can be used to considerable methods and insight for the fundamental research of the material basis of similar healthcare food." @default.
- W4300603118 created "2022-10-03" @default.
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- W4300603118 date "2023-01-01" @default.
- W4300603118 modified "2023-10-04" @default.
- W4300603118 title "Screening hepatoprotective effective components of Lonicerae japonica Flos based on the spectrum-effect relationship and its mechanism exploring" @default.
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- W4300603118 doi "https://doi.org/10.1016/j.fshw.2022.07.018" @default.
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