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- W4300636737 abstract "The control of pattern formation, cell differentiation and cell proliferation in hydroids involves inhibitory signals. In an attempt to identify their chemical nature, compounds from coelenterates which interfere with metamorphosis and pattern-forming processes in Hydractinia and Eirene were isolated. The most strongly metamorphosis-inhibiting compounds were determined to be N-methylpicolinic acid (homarine), N-methylnicotinic acid (trigonelline) and N-trimethylglycine (betaine). The overal concentration of these compounds within tissues is in the range of several millimoles, but micromolar quantities were found to affect development. Thus, the substances must be mainly present in a stored or an inactivated form. The compounds appear to exert their influence by transfering methyl groups to as yet unknown targets. Chemically related compounds that are not able to function as methyl donors have no or only a much lower inhibitory influence, while potential methyl or ethyl donors such as methionine and ethionine have a strong inhibitory influence. Cycloleucine, a competitor with methionine in the production of S-adenosyl-methionine (SAM), and sinefungin, a competitor with SAM in transmethylation, interfere with the intrinsic morphogenetically active compounds identified. One of the spatial patterns controlled by inhibitory signals is the distance between polyps in colonies. In Eirene, the addition of N-methylpicolinic acid led to an increase in the interpolyp distance, while sinefungin produced a decrease in this distance. The addition of sinefungin also stimulated stolon branching. Thus, control of methylation appears to play a key role in the control of metamorphosis and pattern formation in hydrozoa." @default.
- W4300636737 created "2022-10-03" @default.
- W4300636737 date "1977-12-01" @default.
- W4300636737 modified "2023-10-14" @default.
- W4300636737 title "Cumulative subject index Volumes 26–27" @default.
- W4300636737 doi "https://doi.org/10.1016/0014-4800(77)90013-2" @default.
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