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- W4300643772 abstract "Experiments performed during spaceflight clearly show that several cellular processes, such as oxidative metabolism, growth rates, signaling pathways and gene expression, are modified under conditions of weightlessness [1]. In particular, it has been suggested that reduced growth response in lymphocytes during spaceflight might be linked to apoptosis, based on morphological detection and cDNA microarray analysis [2] of space-flown human lymphoblastoid (Jurkat) cells. 5-Lipoxygenase (arachidonate:oxygen 5-oxidoreductase, EC 1.13.11.34; 5-LOX) plays a central role in interleukin-2 expression and activation of human lymphocytes, and is involved in the initiation of programmed death (apoptosis) triggered by unrelated stimuli in different human cells (reviewed in ref. 3). [...]" @default.
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- W4300643772 date "1970-01-01" @default.
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- W4300643772 title "Simulated Microgravity Induces Apoptosis in Human Lymphocytes by a 5-Lipoxygenase-Mediated Mechanism" @default.
- W4300643772 doi "https://doi.org/10.4081/jbr.2003.10528" @default.
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