Matches in SemOpenAlex for { <https://semopenalex.org/work/W4300658667> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W4300658667 endingPage "6348" @default.
- W4300658667 startingPage "6340" @default.
- W4300658667 abstract "α-dystroglycan (α-DG) is an agrin-binding protein that has been implicated in acetylcholine receptor (AChR) clustering, but it is unclear whether it acts as a coreceptor involved in initial agrin signaling or as a component involved in later events. To investigate its role, we have generated antisense derivatives of the C2 mouse muscle cell line, which have reduced α-DG expression. When compared with wild-type cells, the α-DG-deficient myotubes have a dramatic reduction in the number of spontaneous and agrin-induced AChR clusters. Several findings suggest that this decrease in AChR clustering is likely not because of a defect in agrin signaling through the MuSK receptor tyrosine kinase. Compared with wild-type cells, the α-DG-deficient cell lines showed only a transient reduction in the level of agrin-induced MuSK tyrosine phosphorylation and no reduction in AChR β-subunit tyrosine phosphorylation. Additionally, agrin-induced phosphorylation of MuSK in wild-type myotubes was not decreased using agrin fragments that lack the domain primarily responsible for binding to α-DG. Finally, neural agrin-induced phosphorylation of MuSK was unaffected by treatments such as excess muscle agrin or anti-α-DG antibodies, both of which block agrin–α-DG binding. Together, these results suggest that α-DG is not required for agrin-MuSK signaling but rather that it may play a role elsewhere in the clustering pathway, such as in the downstream consolidation or maintenance of AChR clusters." @default.
- W4300658667 created "2022-10-03" @default.
- W4300658667 creator A5005667538 @default.
- W4300658667 creator A5026776030 @default.
- W4300658667 creator A5036016735 @default.
- W4300658667 creator A5040937177 @default.
- W4300658667 creator A5041356418 @default.
- W4300658667 date "1998-08-15" @default.
- W4300658667 modified "2023-10-04" @default.
- W4300658667 title "α-Dystroglycan Functions in Acetylcholine Receptor Aggregation But Is Not a Coreceptor for Agrin-MuSK Signaling" @default.
- W4300658667 doi "https://doi.org/10.1523/jneurosci.18-16-06340.1998" @default.
- W4300658667 hasPublicationYear "1998" @default.
- W4300658667 type Work @default.
- W4300658667 citedByCount "54" @default.
- W4300658667 countsByYear W43006586672013 @default.
- W4300658667 countsByYear W43006586672016 @default.
- W4300658667 countsByYear W43006586672017 @default.
- W4300658667 countsByYear W43006586672018 @default.
- W4300658667 countsByYear W43006586672019 @default.
- W4300658667 countsByYear W43006586672020 @default.
- W4300658667 crossrefType "journal-article" @default.
- W4300658667 hasAuthorship W4300658667A5005667538 @default.
- W4300658667 hasAuthorship W4300658667A5026776030 @default.
- W4300658667 hasAuthorship W4300658667A5036016735 @default.
- W4300658667 hasAuthorship W4300658667A5040937177 @default.
- W4300658667 hasAuthorship W4300658667A5041356418 @default.
- W4300658667 hasBestOaLocation W43006586671 @default.
- W4300658667 hasConcept C101544691 @default.
- W4300658667 hasConcept C11960822 @default.
- W4300658667 hasConcept C169760540 @default.
- W4300658667 hasConcept C170493617 @default.
- W4300658667 hasConcept C185592680 @default.
- W4300658667 hasConcept C189165786 @default.
- W4300658667 hasConcept C207200792 @default.
- W4300658667 hasConcept C2776165026 @default.
- W4300658667 hasConcept C2777240379 @default.
- W4300658667 hasConcept C2777553839 @default.
- W4300658667 hasConcept C2778384963 @default.
- W4300658667 hasConcept C2779024559 @default.
- W4300658667 hasConcept C2779814568 @default.
- W4300658667 hasConcept C3763915 @default.
- W4300658667 hasConcept C55493867 @default.
- W4300658667 hasConcept C80161118 @default.
- W4300658667 hasConcept C86803240 @default.
- W4300658667 hasConcept C95444343 @default.
- W4300658667 hasConceptScore W4300658667C101544691 @default.
- W4300658667 hasConceptScore W4300658667C11960822 @default.
- W4300658667 hasConceptScore W4300658667C169760540 @default.
- W4300658667 hasConceptScore W4300658667C170493617 @default.
- W4300658667 hasConceptScore W4300658667C185592680 @default.
- W4300658667 hasConceptScore W4300658667C189165786 @default.
- W4300658667 hasConceptScore W4300658667C207200792 @default.
- W4300658667 hasConceptScore W4300658667C2776165026 @default.
- W4300658667 hasConceptScore W4300658667C2777240379 @default.
- W4300658667 hasConceptScore W4300658667C2777553839 @default.
- W4300658667 hasConceptScore W4300658667C2778384963 @default.
- W4300658667 hasConceptScore W4300658667C2779024559 @default.
- W4300658667 hasConceptScore W4300658667C2779814568 @default.
- W4300658667 hasConceptScore W4300658667C3763915 @default.
- W4300658667 hasConceptScore W4300658667C55493867 @default.
- W4300658667 hasConceptScore W4300658667C80161118 @default.
- W4300658667 hasConceptScore W4300658667C86803240 @default.
- W4300658667 hasConceptScore W4300658667C95444343 @default.
- W4300658667 hasIssue "16" @default.
- W4300658667 hasLocation W43006586671 @default.
- W4300658667 hasLocation W43006586672 @default.
- W4300658667 hasLocation W43006586673 @default.
- W4300658667 hasLocation W43006586674 @default.
- W4300658667 hasOpenAccess W4300658667 @default.
- W4300658667 hasPrimaryLocation W43006586671 @default.
- W4300658667 hasRelatedWork W1579929193 @default.
- W4300658667 hasRelatedWork W1964668015 @default.
- W4300658667 hasRelatedWork W1984604208 @default.
- W4300658667 hasRelatedWork W1998603197 @default.
- W4300658667 hasRelatedWork W2028266925 @default.
- W4300658667 hasRelatedWork W2047015631 @default.
- W4300658667 hasRelatedWork W2062955445 @default.
- W4300658667 hasRelatedWork W2067808461 @default.
- W4300658667 hasRelatedWork W2087893167 @default.
- W4300658667 hasRelatedWork W2091528937 @default.
- W4300658667 hasVolume "18" @default.
- W4300658667 isParatext "false" @default.
- W4300658667 isRetracted "false" @default.
- W4300658667 workType "article" @default.