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• W4300659905 abstract "Structural biology methods presently play a significant role in the development of new therapeutic drugs such as approaches for cancer therapies. Structural biology is fundamental for recognizing how proteins and genes function and provides us with the necessary clues to design effective cancer therapies. X-ray crystallography has been established to be a dominant instrument in an essential method for the design and development of new compounds with improved affinity and specificity. It can provide delicately complete structural information concerning the interaction of a ligand with a drug or pharmacological target. Fragment-Based Screening has emerged with X-ray Crystallography has turned into an influential screening technology, capable of providing structural information in complexes that involve low-molecular-weight compounds, although with weak binding affinities. The current drug discovery process is extremely complex and requires multidisciplinary efforts and action in cancer therapeutics. Cancer drug development and discovery are leading the way in utilizing molecular biological and genetic information for developing medicine. In this chapter, we discuss the role of structural biology, including using X-ray crystallography and its role in drug development, with a special focus on the status of the development and discovery of cancer therapeutics. We further discussed how structural biology and systems biology are integrated and give rise to a relatively new domain called “structural systems biology.”" @default.
• W4300659905 created "2022-10-03" @default.
• W4300659905 creator A5026586222 @default.
• W4300659905 creator A5064046988 @default.
• W4300659905 creator A5087775910 @default.
• W4300659905 date "2022-01-01" @default.
• W4300659905 modified "2023-09-27" @default.
• W4300659905 title "Emerging Role of Structural and Systems Biology in Anticancer Therapeutics" @default.
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