Matches in SemOpenAlex for { <https://semopenalex.org/work/W4300688315> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W4300688315 endingPage "9" @default.
- W4300688315 startingPage "1" @default.
- W4300688315 abstract "Abstract Background: There is a paucity of information reported regarding the use of milrinone in patients with hypoplastic left heart syndrome prior to the Norwood procedure. At our institution, milrinone is initiated in the pre-operative setting when over-circulation and elevated serum lactate levels develop. We aimed to review the responses associated with the administration of milrinone in the pre-operative hypoplastic left heart syndrome patient. Second, we compared patients who received high- versus low-dose milrinone prior to Norwood procedure. Methods: Single-centre retrospective study of patients diagnosed with hypoplastic left heart syndrome between January 2000 and December 2019 who underwent Norwood procedure. Patient characteristics and outcomes were compared. Results: During the study period, 375 patients were identified; 79 (21%) received milrinone prior to the Norwood procedure with median lactate 2.55 mmol/l, and SpO2 93%. Patients who received milrinone were older at the time of Norwood procedure (6 vs. 5 days) and were more likely to be intubated and sedated. In a subset analysis stratifying patients to low- versus high-dose milrinone, median lactate decreased from time of initiation (2.39 vs 2.75 to 1.6 vs 1.8 mmol/l) at 12 hours post-initiation, respectively. Repeated measures analysis showed a significant decrease in lactate levels by 4 hours following initiation of milrinone, that persisted over time, with no significant difference in mean arterial pressure. Conclusions: The use of milrinone in the pre-operative over-circulated hypoplastic left heart syndrome patient is well tolerated, is associated with decreased lactate levels, and was not associated with significant hypotension or worsening of excess pulmonary blood flow." @default.
- W4300688315 created "2022-10-04" @default.
- W4300688315 creator A5001331901 @default.
- W4300688315 creator A5004714700 @default.
- W4300688315 creator A5016806649 @default.
- W4300688315 creator A5045929691 @default.
- W4300688315 creator A5055162379 @default.
- W4300688315 creator A5069407462 @default.
- W4300688315 creator A5073584790 @default.
- W4300688315 creator A5074724767 @default.
- W4300688315 date "2022-10-03" @default.
- W4300688315 modified "2023-09-27" @default.
- W4300688315 title "Milrinone for treatment of elevated lactate in the pre-operative newborn with hypoplastic left heart syndrome" @default.
- W4300688315 cites W1982942826 @default.
- W4300688315 cites W1998783376 @default.
- W4300688315 cites W2000060940 @default.
- W4300688315 cites W2029791054 @default.
- W4300688315 cites W2051636485 @default.
- W4300688315 cites W2053609738 @default.
- W4300688315 cites W2074878994 @default.
- W4300688315 cites W2090949113 @default.
- W4300688315 cites W2109483448 @default.
- W4300688315 cites W2124438175 @default.
- W4300688315 cites W2141900287 @default.
- W4300688315 cites W2143313575 @default.
- W4300688315 cites W2313604358 @default.
- W4300688315 cites W2535578619 @default.
- W4300688315 cites W2547895602 @default.
- W4300688315 cites W2553952607 @default.
- W4300688315 cites W2995322848 @default.
- W4300688315 cites W3044158187 @default.
- W4300688315 cites W3128032294 @default.
- W4300688315 doi "https://doi.org/10.1017/s1047951122003171" @default.
- W4300688315 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36184833" @default.
- W4300688315 hasPublicationYear "2022" @default.
- W4300688315 type Work @default.
- W4300688315 citedByCount "0" @default.
- W4300688315 crossrefType "journal-article" @default.
- W4300688315 hasAuthorship W4300688315A5001331901 @default.
- W4300688315 hasAuthorship W4300688315A5004714700 @default.
- W4300688315 hasAuthorship W4300688315A5016806649 @default.
- W4300688315 hasAuthorship W4300688315A5045929691 @default.
- W4300688315 hasAuthorship W4300688315A5055162379 @default.
- W4300688315 hasAuthorship W4300688315A5069407462 @default.
- W4300688315 hasAuthorship W4300688315A5073584790 @default.
- W4300688315 hasAuthorship W4300688315A5074724767 @default.
- W4300688315 hasBestOaLocation W43006883151 @default.
- W4300688315 hasConcept C126322002 @default.
- W4300688315 hasConcept C141071460 @default.
- W4300688315 hasConcept C164705383 @default.
- W4300688315 hasConcept C178853913 @default.
- W4300688315 hasConcept C2776053971 @default.
- W4300688315 hasConcept C2776645727 @default.
- W4300688315 hasConcept C2779545397 @default.
- W4300688315 hasConcept C2780074459 @default.
- W4300688315 hasConcept C42219234 @default.
- W4300688315 hasConcept C71924100 @default.
- W4300688315 hasConceptScore W4300688315C126322002 @default.
- W4300688315 hasConceptScore W4300688315C141071460 @default.
- W4300688315 hasConceptScore W4300688315C164705383 @default.
- W4300688315 hasConceptScore W4300688315C178853913 @default.
- W4300688315 hasConceptScore W4300688315C2776053971 @default.
- W4300688315 hasConceptScore W4300688315C2776645727 @default.
- W4300688315 hasConceptScore W4300688315C2779545397 @default.
- W4300688315 hasConceptScore W4300688315C2780074459 @default.
- W4300688315 hasConceptScore W4300688315C42219234 @default.
- W4300688315 hasConceptScore W4300688315C71924100 @default.
- W4300688315 hasLocation W43006883151 @default.
- W4300688315 hasLocation W43006883152 @default.
- W4300688315 hasOpenAccess W4300688315 @default.
- W4300688315 hasPrimaryLocation W43006883151 @default.
- W4300688315 hasRelatedWork W1993798130 @default.
- W4300688315 hasRelatedWork W2768182118 @default.
- W4300688315 hasRelatedWork W2900449241 @default.
- W4300688315 hasRelatedWork W3128032294 @default.
- W4300688315 hasRelatedWork W3153530731 @default.
- W4300688315 hasRelatedWork W4298052976 @default.
- W4300688315 hasRelatedWork W4300688315 @default.
- W4300688315 hasRelatedWork W4322727868 @default.
- W4300688315 hasRelatedWork W4365136227 @default.
- W4300688315 hasRelatedWork W2149061682 @default.
- W4300688315 isParatext "false" @default.
- W4300688315 isRetracted "false" @default.
- W4300688315 workType "article" @default.