Matches in SemOpenAlex for { <https://semopenalex.org/work/W4300688628> ?p ?o ?g. }
- W4300688628 abstract "Bird cardiomyocytes are long, thin and lack transverse (t)-tubules, which is akin to the cardiomyocyte morphology of ectothermic non-avian reptiles, who are typified by low maximum heart rates and low pressure development. However, birds can achieve greater contractile rates and developed pressures than mammals, whose wide cardiomyocytes contain a dense t-tubular network allowing for uniform excitation-contraction coupling and strong contractile force. To address this apparent paradox, this paper functionally links recent electrophysiological studies on bird cardiomyocytes with decades of ultrastructure measurements. It shows that it is the strong transsarcolemmal Ca2+ influx via the L-type Ca2+ current (ICaL) and the high gain of Ca2+-induced Ca2+ release from the sarcoplasmic reticulum (SR), coupled with an internal SR Ca2+ release relay system, that facilitates the strong fast contractions in the long thin bird cardiomyocytes, without the need for t-tubules. The maintenance of an elongated myocyte morphology following the post-hatch transition from ectothermy to endothermy in birds is discussed in relation to cardiac load, myocyte ploidy, and cardiac regeneration potential in adult cardiomyocytes. Overall, the paper shows how little we know about cellular Ca2+ dynamics in the bird heart and suggests how increased research efforts in this area would provide vital information in our quest to understand the role of myocyte architecture in the evolution of the vertebrate heart. This article is part of the theme issue 'The cardiomyocyte: new revelations on the interplay between architecture and function in growth, health, and disease'. Please see glossary at the end of the paper for definitions of specialized terms." @default.
- W4300688628 created "2022-10-04" @default.
- W4300688628 creator A5047962515 @default.
- W4300688628 date "2022-10-03" @default.
- W4300688628 modified "2023-10-18" @default.
- W4300688628 title "Avian cardiomyocyte architecture and what it reveals about the evolution of the vertebrate heart" @default.
- W4300688628 cites W1238563228 @default.
- W4300688628 cites W1527393532 @default.
- W4300688628 cites W1854301971 @default.
- W4300688628 cites W1966195387 @default.
- W4300688628 cites W1966385214 @default.
- W4300688628 cites W1970896711 @default.
- W4300688628 cites W1972063745 @default.
- W4300688628 cites W1972614588 @default.
- W4300688628 cites W1972701743 @default.
- W4300688628 cites W1973673960 @default.
- W4300688628 cites W1975641338 @default.
- W4300688628 cites W1977241065 @default.
- W4300688628 cites W1978041489 @default.
- W4300688628 cites W1983707293 @default.
- W4300688628 cites W1984340024 @default.
- W4300688628 cites W1985578759 @default.
- W4300688628 cites W1987691163 @default.
- W4300688628 cites W2000202306 @default.
- W4300688628 cites W2003188967 @default.
- W4300688628 cites W2003328924 @default.
- W4300688628 cites W2006144701 @default.
- W4300688628 cites W2010318153 @default.
- W4300688628 cites W2012577079 @default.
- W4300688628 cites W2012751980 @default.
- W4300688628 cites W2013011061 @default.
- W4300688628 cites W2016210511 @default.
- W4300688628 cites W2018349223 @default.
- W4300688628 cites W2021938587 @default.
- W4300688628 cites W2025065705 @default.
- W4300688628 cites W2027619968 @default.
- W4300688628 cites W2028550146 @default.
- W4300688628 cites W2033072652 @default.
- W4300688628 cites W2036300642 @default.
- W4300688628 cites W2038270377 @default.
- W4300688628 cites W2042619775 @default.
- W4300688628 cites W2045583936 @default.
- W4300688628 cites W2046701128 @default.
- W4300688628 cites W2046754570 @default.
- W4300688628 cites W2054877270 @default.
- W4300688628 cites W2055521852 @default.
- W4300688628 cites W2060450618 @default.
- W4300688628 cites W2061853558 @default.
- W4300688628 cites W2062684112 @default.
- W4300688628 cites W2069389563 @default.
- W4300688628 cites W2074489447 @default.
- W4300688628 cites W2078671382 @default.
- W4300688628 cites W2089489683 @default.
- W4300688628 cites W2090116945 @default.
- W4300688628 cites W2091667684 @default.
- W4300688628 cites W2092036283 @default.
- W4300688628 cites W2098044063 @default.
- W4300688628 cites W2100579413 @default.
- W4300688628 cites W2101417788 @default.
- W4300688628 cites W2105664556 @default.
- W4300688628 cites W2106259616 @default.
- W4300688628 cites W2108044158 @default.
- W4300688628 cites W2109009509 @default.
- W4300688628 cites W2110669729 @default.
- W4300688628 cites W2111773661 @default.
- W4300688628 cites W2112583647 @default.
- W4300688628 cites W2112810806 @default.
- W4300688628 cites W2117298406 @default.
- W4300688628 cites W2120324351 @default.
- W4300688628 cites W2120511972 @default.
- W4300688628 cites W2124488011 @default.
- W4300688628 cites W2125505135 @default.
- W4300688628 cites W2125755819 @default.
- W4300688628 cites W2127539762 @default.
- W4300688628 cites W2130353415 @default.
- W4300688628 cites W2135596278 @default.
- W4300688628 cites W2138341161 @default.
- W4300688628 cites W2138958648 @default.
- W4300688628 cites W2140660269 @default.
- W4300688628 cites W2141636714 @default.
- W4300688628 cites W2142890141 @default.
- W4300688628 cites W2144374865 @default.
- W4300688628 cites W2148211432 @default.
- W4300688628 cites W2148750197 @default.
- W4300688628 cites W2149061431 @default.
- W4300688628 cites W2149323753 @default.
- W4300688628 cites W2154116722 @default.
- W4300688628 cites W2155816865 @default.
- W4300688628 cites W2156510087 @default.
- W4300688628 cites W2156850492 @default.
- W4300688628 cites W2159597311 @default.
- W4300688628 cites W2163016631 @default.
- W4300688628 cites W2165291628 @default.
- W4300688628 cites W2166478912 @default.
- W4300688628 cites W2167902707 @default.
- W4300688628 cites W2170908011 @default.
- W4300688628 cites W2171422564 @default.
- W4300688628 cites W2215857688 @default.
- W4300688628 cites W2226437153 @default.
- W4300688628 cites W2238210638 @default.