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- W4300689171 abstract "We herein report the use of phenyl trimethylammonium iodide (PhMe3NI) as a safe, nontoxic, and easy-to-handle reagent for an absolutely monoselective N-methylation of amides and related compounds as well as for the N-methylation of indoles. In addition, we expanded the method to N-ethylation using PhEt3NI. The ease of operational setup, high yields of ≤99%, high functional group tolerance, and especially the excellent monoselectivity for amides make this method attractive for late-stage methylation of bioactive compounds." @default.
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- W4300689171 date "2022-10-03" @default.
- W4300689171 modified "2023-10-05" @default.
- W4300689171 title "Monoselective N-Methylation of Amides, Indoles, and Related Structures Using Quaternary Ammonium Salts as Solid Methylating Agents" @default.
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- W4300689171 doi "https://doi.org/10.1021/acs.orglett.2c02766" @default.
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