Matches in SemOpenAlex for { <https://semopenalex.org/work/W4300689426> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W4300689426 endingPage "1191" @default.
- W4300689426 startingPage "1183" @default.
- W4300689426 abstract "Hypertensive kidney damage results in glomerular as well as tubular dysfunction. Albuminuria is a well-known marker of glomerular damage. On the other hand, urinary uromodulin is increasingly considered as a potential biomarker of early tubular dysfunction. The aim of the study was to assess glomerular and tubular function of the kidney by measuring urinary albumin and uromodulin excretion in hypertensive subjects. This cross-sectional study was conducted from July 2018 to June 2019 in Hypertension Clinic of Dhaka Medical College Hospital, Dhaka and Kidney Care and Research Centre, Sonargaon, Narayanganj, Bangladesh. In this study 122 hypertensive subjects with age >30 years, duration of hypertension <5 years, without accelerated or malignant BP, absence of dipstick proteinuria and eGFR >60ml/min were included. There were also 33 normotensive individuals included as healthy controls. Albumin-creatinine ratio (uACR mg/g), urine uromodulin-creatinine ratio (uUMODμg/g), urinary sodium-creatinine ratio (mEq/g) and potassium-creatinine ratio (mEq/g) were measured from single morning spot urine sample. Urinary uromodulin levels were measured by ELISA method. The hypertensive and normotensive subjects were age matched 49.0±12.0 vs. 48.0±11.0, years (p=NS). The mean uACR was 29.0±65.0 versus 5.6±2.7mg/g, (p<0.001) respectively. The median uUMOD in hypertensive subjects was 3.38 (1.73-9.06) and in normotensives 3.85(2.28-5.69) μg/g (p=non significant). Multivariate analysis showed significant inverse association between diastolic blood pressure and urinary uromodulin excretion. A uUMOD cut-off of 2.9 (25th percentile) showed eGFR, urinary sodium and potassium excretions were significantly lower at low uromodulin group. The glomerular involvement was found in 21.0% of hypertensive subjects as evidenced by albuminuria. No difference was observed in urinary uromodulin level between hypertensive and normotensive subjects. Low urinary uromodulin level was associated with lower eGFR, Na+ and K+ excretion which indicate simultaneous tubular and glomerular involvement." @default.
- W4300689426 created "2022-10-04" @default.
- W4300689426 creator A5006360267 @default.
- W4300689426 creator A5010567075 @default.
- W4300689426 creator A5026161936 @default.
- W4300689426 creator A5027356283 @default.
- W4300689426 creator A5037346274 @default.
- W4300689426 creator A5066075195 @default.
- W4300689426 creator A5069719328 @default.
- W4300689426 creator A5079279926 @default.
- W4300689426 creator A5085963973 @default.
- W4300689426 date "2022-10-01" @default.
- W4300689426 modified "2023-09-27" @default.
- W4300689426 title "Evaluation of Early Renal Involvement in Essential Hypertension by Measuring Urinary Biomarkers." @default.
- W4300689426 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36189570" @default.
- W4300689426 hasPublicationYear "2022" @default.
- W4300689426 type Work @default.
- W4300689426 citedByCount "0" @default.
- W4300689426 crossrefType "journal-article" @default.
- W4300689426 hasAuthorship W4300689426A5006360267 @default.
- W4300689426 hasAuthorship W4300689426A5010567075 @default.
- W4300689426 hasAuthorship W4300689426A5026161936 @default.
- W4300689426 hasAuthorship W4300689426A5027356283 @default.
- W4300689426 hasAuthorship W4300689426A5037346274 @default.
- W4300689426 hasAuthorship W4300689426A5066075195 @default.
- W4300689426 hasAuthorship W4300689426A5069719328 @default.
- W4300689426 hasAuthorship W4300689426A5079279926 @default.
- W4300689426 hasAuthorship W4300689426A5085963973 @default.
- W4300689426 hasConcept C10146269 @default.
- W4300689426 hasConcept C126322002 @default.
- W4300689426 hasConcept C126894567 @default.
- W4300689426 hasConcept C134018914 @default.
- W4300689426 hasConcept C159641895 @default.
- W4300689426 hasConcept C2776174234 @default.
- W4300689426 hasConcept C2777097880 @default.
- W4300689426 hasConcept C2779561371 @default.
- W4300689426 hasConcept C2779922275 @default.
- W4300689426 hasConcept C2780026642 @default.
- W4300689426 hasConcept C2780091579 @default.
- W4300689426 hasConcept C2780306776 @default.
- W4300689426 hasConcept C2910852105 @default.
- W4300689426 hasConcept C71924100 @default.
- W4300689426 hasConcept C74460091 @default.
- W4300689426 hasConcept C77411442 @default.
- W4300689426 hasConcept C84393581 @default.
- W4300689426 hasConceptScore W4300689426C10146269 @default.
- W4300689426 hasConceptScore W4300689426C126322002 @default.
- W4300689426 hasConceptScore W4300689426C126894567 @default.
- W4300689426 hasConceptScore W4300689426C134018914 @default.
- W4300689426 hasConceptScore W4300689426C159641895 @default.
- W4300689426 hasConceptScore W4300689426C2776174234 @default.
- W4300689426 hasConceptScore W4300689426C2777097880 @default.
- W4300689426 hasConceptScore W4300689426C2779561371 @default.
- W4300689426 hasConceptScore W4300689426C2779922275 @default.
- W4300689426 hasConceptScore W4300689426C2780026642 @default.
- W4300689426 hasConceptScore W4300689426C2780091579 @default.
- W4300689426 hasConceptScore W4300689426C2780306776 @default.
- W4300689426 hasConceptScore W4300689426C2910852105 @default.
- W4300689426 hasConceptScore W4300689426C71924100 @default.
- W4300689426 hasConceptScore W4300689426C74460091 @default.
- W4300689426 hasConceptScore W4300689426C77411442 @default.
- W4300689426 hasConceptScore W4300689426C84393581 @default.
- W4300689426 hasIssue "4" @default.
- W4300689426 hasLocation W43006894261 @default.
- W4300689426 hasOpenAccess W4300689426 @default.
- W4300689426 hasPrimaryLocation W43006894261 @default.
- W4300689426 hasRelatedWork W1978700980 @default.
- W4300689426 hasRelatedWork W2350984489 @default.
- W4300689426 hasRelatedWork W2369552721 @default.
- W4300689426 hasRelatedWork W2410604121 @default.
- W4300689426 hasRelatedWork W3083666121 @default.
- W4300689426 hasRelatedWork W3132812123 @default.
- W4300689426 hasRelatedWork W3148712325 @default.
- W4300689426 hasRelatedWork W3167002191 @default.
- W4300689426 hasRelatedWork W3199424184 @default.
- W4300689426 hasRelatedWork W4300689426 @default.
- W4300689426 hasVolume "31" @default.
- W4300689426 isParatext "false" @default.
- W4300689426 isRetracted "false" @default.
- W4300689426 workType "article" @default.