Matches in SemOpenAlex for { <https://semopenalex.org/work/W4300689622> ?p ?o ?g. }
- W4300689622 endingPage "112" @default.
- W4300689622 startingPage "105" @default.
- W4300689622 abstract "Objective To assess the available clinical and economic evidence of erenumab vs onabotulinumtoxinA for chronic migraine (CM) and present de-novo indirect treatment comparisons (ITCs) based on available clinical trial data.Methods We conducted ITCs based on results from the pivotal 295 trial (NCT02066415) of erenumab vs placebo and published aggregate data from the PREEMPT 1 (NCT00156910) and PREEMPT 2 (NCT00168428) trials of onabotulinumtoxinA vs placebo. ITCs were conducted for CM patients with and without prior administration of onabotulinumtoxinA and among CM patients with ≥3 prior preventive treatment failures. Efficacy was assessed based on responder rates of ≥50% reductions in monthly headache days (MHDs) and monthly migraine days (MMDs) as well as change from baseline in both MHDs and MMDs.Results Among patients with CM, 140 mg erenumab was associated with a reduction of 1.2 MHD (p = .092) and a reduction of 1.0 MMD (p = .174) compared to onabotulinumtoxinA at Week 12. Among onabotulinumtoxinA-naïve patients, erenumab was associated with a reduction of 1.8 MHD (p = .026) and 1.4 MMD (p = .080) at Week 12. Among patients that had received ≥3 prior preventive treatments, the odds ratios comparing erenumab vs onabotulinumtoxinA were 1.7 for ≥50% responder rates based on reductions in MHD (p = .155) and 1.7 for ≥50% responder rates based on reductions in MMD (p = .140).Conclusion These findings suggest directional benefits (although not reaching the threshold of statistical significance) associated with erenumab vs onabotulinumtoxinA for the preventive treatment of CM. Evidence from this study may inform healthcare stakeholders in treatment selection and optimization for patients with CM." @default.
- W4300689622 created "2022-10-04" @default.
- W4300689622 creator A5000947848 @default.
- W4300689622 creator A5004135550 @default.
- W4300689622 creator A5025738365 @default.
- W4300689622 creator A5048661449 @default.
- W4300689622 creator A5051500813 @default.
- W4300689622 creator A5062272082 @default.
- W4300689622 creator A5062308281 @default.
- W4300689622 creator A5065311807 @default.
- W4300689622 creator A5072063844 @default.
- W4300689622 date "2022-10-13" @default.
- W4300689622 modified "2023-09-23" @default.
- W4300689622 title "Assessment of the relative effectiveness of erenumab compared with onabotulinumtoxinA for the prevention of chronic migraine" @default.
- W4300689622 cites W1987630964 @default.
- W4300689622 cites W1995054730 @default.
- W4300689622 cites W2005947177 @default.
- W4300689622 cites W2007410119 @default.
- W4300689622 cites W2029991935 @default.
- W4300689622 cites W2032593044 @default.
- W4300689622 cites W2055290905 @default.
- W4300689622 cites W2062818994 @default.
- W4300689622 cites W2067656815 @default.
- W4300689622 cites W2073873452 @default.
- W4300689622 cites W2111548432 @default.
- W4300689622 cites W2114736324 @default.
- W4300689622 cites W2116458765 @default.
- W4300689622 cites W2137787323 @default.
- W4300689622 cites W2148445312 @default.
- W4300689622 cites W2167719770 @default.
- W4300689622 cites W2325770952 @default.
- W4300689622 cites W2556396441 @default.
- W4300689622 cites W2608751463 @default.
- W4300689622 cites W2743939179 @default.
- W4300689622 cites W2751884637 @default.
- W4300689622 cites W2763655322 @default.
- W4300689622 cites W2789266701 @default.
- W4300689622 cites W2789799969 @default.
- W4300689622 cites W2792811290 @default.
- W4300689622 cites W2793946385 @default.
- W4300689622 cites W2891090436 @default.
- W4300689622 cites W2893409070 @default.
- W4300689622 cites W2956772508 @default.
- W4300689622 cites W2970706487 @default.
- W4300689622 cites W2982541883 @default.
- W4300689622 cites W2997427223 @default.
- W4300689622 cites W3020424199 @default.
- W4300689622 cites W3023835061 @default.
- W4300689622 cites W3027979090 @default.
- W4300689622 cites W3029690557 @default.
- W4300689622 cites W3030140473 @default.
- W4300689622 cites W3096991256 @default.
- W4300689622 cites W3109911524 @default.
- W4300689622 cites W3110656045 @default.
- W4300689622 cites W3119715732 @default.
- W4300689622 cites W3126007787 @default.
- W4300689622 cites W3137761428 @default.
- W4300689622 cites W3147563610 @default.
- W4300689622 cites W3154454412 @default.
- W4300689622 cites W3157326277 @default.
- W4300689622 cites W3176461052 @default.
- W4300689622 cites W4230120862 @default.
- W4300689622 doi "https://doi.org/10.1080/03007995.2022.2131299" @default.
- W4300689622 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36189948" @default.
- W4300689622 hasPublicationYear "2022" @default.
- W4300689622 type Work @default.
- W4300689622 citedByCount "1" @default.
- W4300689622 countsByYear W43006896222023 @default.
- W4300689622 crossrefType "journal-article" @default.
- W4300689622 hasAuthorship W4300689622A5000947848 @default.
- W4300689622 hasAuthorship W4300689622A5004135550 @default.
- W4300689622 hasAuthorship W4300689622A5025738365 @default.
- W4300689622 hasAuthorship W4300689622A5048661449 @default.
- W4300689622 hasAuthorship W4300689622A5051500813 @default.
- W4300689622 hasAuthorship W4300689622A5062272082 @default.
- W4300689622 hasAuthorship W4300689622A5062308281 @default.
- W4300689622 hasAuthorship W4300689622A5065311807 @default.
- W4300689622 hasAuthorship W4300689622A5072063844 @default.
- W4300689622 hasConcept C126322002 @default.
- W4300689622 hasConcept C142724271 @default.
- W4300689622 hasConcept C1862650 @default.
- W4300689622 hasConcept C204787440 @default.
- W4300689622 hasConcept C27081682 @default.
- W4300689622 hasConcept C2778541695 @default.
- W4300689622 hasConcept C2910587157 @default.
- W4300689622 hasConcept C535046627 @default.
- W4300689622 hasConcept C65409693 @default.
- W4300689622 hasConcept C71924100 @default.
- W4300689622 hasConceptScore W4300689622C126322002 @default.
- W4300689622 hasConceptScore W4300689622C142724271 @default.
- W4300689622 hasConceptScore W4300689622C1862650 @default.
- W4300689622 hasConceptScore W4300689622C204787440 @default.
- W4300689622 hasConceptScore W4300689622C27081682 @default.
- W4300689622 hasConceptScore W4300689622C2778541695 @default.
- W4300689622 hasConceptScore W4300689622C2910587157 @default.
- W4300689622 hasConceptScore W4300689622C535046627 @default.
- W4300689622 hasConceptScore W4300689622C65409693 @default.
- W4300689622 hasConceptScore W4300689622C71924100 @default.