FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4300689744> ?p ?o ?g. }

• W4300689744 endingPage "2709" @default.
• W4300689744 startingPage "2704" @default.
• W4300689744 abstract "Nanopore direct RNA sequencing (dRNA-Seq) reads reveal RNA modifications through consistent error profiles specific to a modified nucleobase. However, a null data set is required to identify actual RNA modification-associated errors for distinguishing it from confounding highly intrinsic sequencing errors. Here, we reveal that inosine creates a signature mismatch error in dRNA-Seq reads and obviates the need for a null data set by harnessing the selective reactivity of acrylonitrile for validating the presence of actual inosine modifications. Selective reactivity of acrylonitrile toward inosine altered multiple dRNA-Seq parameters like signal intensity and trace value. We also deduced the stoichiometry of inosine modification through deviation in signal intensity and trace value using this chemical biology approach. Furthermore, we devised Nano ICE-Seq, a protocol to overcome the low coverage issue associated with direct RNA sequencing. Taken together, our chemical probe-based approach may facilitate the knockout-free detection of disease-associated RNA modifications in clinical scenarios." @default.
• W4300689744 created "2022-10-04" @default.
• W4300689744 creator A5002713160 @default.
• W4300689744 creator A5025484696 @default.
• W4300689744 creator A5036858748 @default.
• W4300689744 creator A5038984650 @default.
• W4300689744 creator A5052430096 @default.
• W4300689744 creator A5060896745 @default.
• W4300689744 creator A5063454117 @default.
• W4300689744 creator A5070714958 @default.
• W4300689744 creator A5077130141 @default.
• W4300689744 date "2022-10-03" @default.
• W4300689744 modified "2023-10-15" @default.
• W4300689744 title "Chemical Probe-Based Nanopore Sequencing to Selectively Assess the RNA Modifications" @default.
• W4300689744 cites W1500914927 @default.
• W4300689744 cites W1606920356 @default.
• W4300689744 cites W1978974023 @default.
• W4300689744 cites W2005259783 @default.
• W4300689744 cites W2054584406 @default.
• W4300689744 cites W2058647478 @default.
• W4300689744 cites W2074562954 @default.
• W4300689744 cites W2094583488 @default.
• W4300689744 cites W2120276342 @default.
• W4300689744 cites W2127407003 @default.
• W4300689744 cites W2133123387 @default.
• W4300689744 cites W2280633723 @default.
• W4300689744 cites W2401675373 @default.
• W4300689744 cites W2510286488 @default.
• W4300689744 cites W2582252439 @default.
• W4300689744 cites W2760498857 @default.
• W4300689744 cites W2765641908 @default.
• W4300689744 cites W2889415094 @default.
• W4300689744 cites W2903736884 @default.
• W4300689744 cites W2915489297 @default.
• W4300689744 cites W2922152634 @default.
• W4300689744 cites W2949707636 @default.
• W4300689744 cites W2950063384 @default.
• W4300689744 cites W2950368366 @default.
• W4300689744 cites W2971454256 @default.
• W4300689744 cites W3010488797 @default.
• W4300689744 cites W3027253833 @default.
• W4300689744 cites W3043981686 @default.
• W4300689744 cites W3162353597 @default.
• W4300689744 cites W3199440159 @default.
• W4300689744 cites W4200167258 @default.
• W4300689744 cites W4299544926 @default.
• W4300689744 doi "https://doi.org/10.1021/acschembio.2c00221" @default.
• W4300689744 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36190780" @default.
• W4300689744 hasPublicationYear "2022" @default.
• W4300689744 type Work @default.
• W4300689744 citedByCount "5" @default.
• W4300689744 countsByYear W43006897442022 @default.
• W4300689744 countsByYear W43006897442023 @default.
• W4300689744 crossrefType "journal-article" @default.
• W4300689744 hasAuthorship W4300689744A5002713160 @default.
• W4300689744 hasAuthorship W4300689744A5025484696 @default.
• W4300689744 hasAuthorship W4300689744A5036858748 @default.
• W4300689744 hasAuthorship W4300689744A5038984650 @default.
• W4300689744 hasAuthorship W4300689744A5052430096 @default.
• W4300689744 hasAuthorship W4300689744A5060896745 @default.
• W4300689744 hasAuthorship W4300689744A5063454117 @default.
• W4300689744 hasAuthorship W4300689744A5070714958 @default.
• W4300689744 hasAuthorship W4300689744A5077130141 @default.
• W4300689744 hasBestOaLocation W43006897442 @default.
• W4300689744 hasConcept C104317684 @default.
• W4300689744 hasConcept C126513998 @default.
• W4300689744 hasConcept C141795571 @default.
• W4300689744 hasConcept C171250308 @default.
• W4300689744 hasConcept C192562407 @default.
• W4300689744 hasConcept C2776991684 @default.
• W4300689744 hasConcept C2777610669 @default.
• W4300689744 hasConcept C41008148 @default.
• W4300689744 hasConcept C51679486 @default.
• W4300689744 hasConcept C54355233 @default.
• W4300689744 hasConcept C55493867 @default.
• W4300689744 hasConcept C67705224 @default.
• W4300689744 hasConcept C70721500 @default.
• W4300689744 hasConcept C86803240 @default.
• W4300689744 hasConceptScore W4300689744C104317684 @default.
• W4300689744 hasConceptScore W4300689744C126513998 @default.
• W4300689744 hasConceptScore W4300689744C141795571 @default.
• W4300689744 hasConceptScore W4300689744C171250308 @default.
• W4300689744 hasConceptScore W4300689744C192562407 @default.
• W4300689744 hasConceptScore W4300689744C2776991684 @default.
• W4300689744 hasConceptScore W4300689744C2777610669 @default.
• W4300689744 hasConceptScore W4300689744C41008148 @default.
• W4300689744 hasConceptScore W4300689744C51679486 @default.
• W4300689744 hasConceptScore W4300689744C54355233 @default.
• W4300689744 hasConceptScore W4300689744C55493867 @default.
• W4300689744 hasConceptScore W4300689744C67705224 @default.
• W4300689744 hasConceptScore W4300689744C70721500 @default.
• W4300689744 hasConceptScore W4300689744C86803240 @default.
• W4300689744 hasFunder F4320308304 @default.
• W4300689744 hasFunder F4320311405 @default.
• W4300689744 hasFunder F4320312581 @default.
• W4300689744 hasFunder F4320320912 @default.
• W4300689744 hasFunder F4320334764 @default.
• W4300689744 hasFunder F4320337350 @default.

• next