FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4300690122> ?p ?o ?g. }

• W4300690122 endingPage "e0275371" @default.
• W4300690122 startingPage "e0275371" @default.
• W4300690122 abstract "Methamphetamine (MA) use disorder is an important public health concern. MA withdrawal is often the first step in ceasing or reducing use. There are no evidence-based withdrawal treatments, and no medication is approved for the treatment of MA withdrawal. Lisdexamfetamine (LDX) dimesilate, used in the treatment of attention deficit hyperactivity disorder and binge eating disorder has the potential as an agonist therapy to ameliorate withdrawal symptoms, and improve outcomes for patients.A single arm, open-label pilot study to test the safety and feasibility of LDX for the treatment of MA withdrawal. Participants will be inpatients in a drug and alcohol withdrawal unit, and will receive a tapering dose of LDX over five days: 250mg LDX on Day 1, reducing by 50mg per day to 50mg on Day 5. Optional inpatient Days 6 and 7 will allow for participants to transition to ongoing treatment. Participants will be followed-up on Days 14, 21 and 28. All participants will also receive standard inpatient withdrawal care. The primary outcomes are safety (measured by adverse events, changes in vital signs, changes in suicidality and psychosis) and feasibility (the time taken to enrol the sample, proportion of screen / pre-screen failures). Secondary outcomes are acceptability (treatment satisfaction questionnaire, medication adherence, concomitant medications, qualitative interviews), retention to protocol (proportion retained to primary and secondary endpoints), changes in withdrawal symptoms (Amphetamine Withdrawal Questionnaire) and craving for MA (visual analogue scale), and sleep outcomes (continuous actigraphy and daily sleep diary).This is the first study to assess lisdexamfetamine for the treatment of acute MA withdrawal. If safe and feasible results will go to informing the development of multi-centre randomised controlled trials to determine the efficacy of the intervention." @default.
• W4300690122 created "2022-10-04" @default.
• W4300690122 creator A5011208640 @default.
• W4300690122 creator A5028911674 @default.
• W4300690122 creator A5029122414 @default.
• W4300690122 creator A5040818661 @default.
• W4300690122 creator A5054648799 @default.
• W4300690122 creator A5057715091 @default.
• W4300690122 creator A5059600880 @default.
• W4300690122 creator A5061750709 @default.
• W4300690122 creator A5076740440 @default.
• W4300690122 creator A5078637043 @default.
• W4300690122 creator A5080372844 @default.
• W4300690122 creator A5090300123 @default.
• W4300690122 date "2022-10-03" @default.
• W4300690122 modified "2023-09-25" @default.
• W4300690122 title "Trial protocol of an open label pilot study of lisdexamfetamine for the treatment of acute methamphetamine withdrawal" @default.
• W4300690122 cites W1070976522 @default.
• W4300690122 cites W1497250823 @default.
• W4300690122 cites W1879399529 @default.
• W4300690122 cites W1947342277 @default.
• W4300690122 cites W1972968676 @default.
• W4300690122 cites W1974432571 @default.
• W4300690122 cites W1974896478 @default.
• W4300690122 cites W1975776257 @default.
• W4300690122 cites W1977790476 @default.
• W4300690122 cites W1988937453 @default.
• W4300690122 cites W1992167600 @default.
• W4300690122 cites W1997738975 @default.
• W4300690122 cites W2009240733 @default.
• W4300690122 cites W2012435382 @default.
• W4300690122 cites W2017157581 @default.
• W4300690122 cites W2018820143 @default.
• W4300690122 cites W2020457020 @default.
• W4300690122 cites W2020844317 @default.
• W4300690122 cites W2021534324 @default.
• W4300690122 cites W2023408858 @default.
• W4300690122 cites W2052464626 @default.
• W4300690122 cites W2053861190 @default.
• W4300690122 cites W2057201407 @default.
• W4300690122 cites W2064835843 @default.
• W4300690122 cites W2072839634 @default.
• W4300690122 cites W2073171215 @default.
• W4300690122 cites W2082494913 @default.
• W4300690122 cites W2093274439 @default.
• W4300690122 cites W2102057063 @default.
• W4300690122 cites W2106369261 @default.
• W4300690122 cites W2120912266 @default.
• W4300690122 cites W2143053050 @default.
• W4300690122 cites W2144176813 @default.
• W4300690122 cites W2144317224 @default.
• W4300690122 cites W2145470773 @default.
• W4300690122 cites W2148083007 @default.
• W4300690122 cites W2150632457 @default.
• W4300690122 cites W2166023752 @default.
• W4300690122 cites W2171811563 @default.
• W4300690122 cites W2264851267 @default.
• W4300690122 cites W2313191740 @default.
• W4300690122 cites W2335698000 @default.
• W4300690122 cites W2396755452 @default.
• W4300690122 cites W2517777642 @default.
• W4300690122 cites W2590794714 @default.
• W4300690122 cites W2608088535 @default.
• W4300690122 cites W2751884637 @default.
• W4300690122 cites W2944434778 @default.
• W4300690122 cites W2981405421 @default.
• W4300690122 cites W3010839704 @default.
• W4300690122 cites W3112949746 @default.
• W4300690122 cites W3173223243 @default.
• W4300690122 doi "https://doi.org/10.1371/journal.pone.0275371" @default.
• W4300690122 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36190973" @default.
• W4300690122 hasPublicationYear "2022" @default.
• W4300690122 type Work @default.
• W4300690122 citedByCount "1" @default.
• W4300690122 countsByYear W43006901222022 @default.
• W4300690122 crossrefType "journal-article" @default.
• W4300690122 hasAuthorship W4300690122A5011208640 @default.
• W4300690122 hasAuthorship W4300690122A5028911674 @default.
• W4300690122 hasAuthorship W4300690122A5029122414 @default.
• W4300690122 hasAuthorship W4300690122A5040818661 @default.
• W4300690122 hasAuthorship W4300690122A5054648799 @default.
• W4300690122 hasAuthorship W4300690122A5057715091 @default.
• W4300690122 hasAuthorship W4300690122A5059600880 @default.
• W4300690122 hasAuthorship W4300690122A5061750709 @default.
• W4300690122 hasAuthorship W4300690122A5076740440 @default.
• W4300690122 hasAuthorship W4300690122A5078637043 @default.
• W4300690122 hasAuthorship W4300690122A5080372844 @default.
• W4300690122 hasAuthorship W4300690122A5090300123 @default.
• W4300690122 hasBestOaLocation W43006901221 @default.
• W4300690122 hasConcept C118552586 @default.
• W4300690122 hasConcept C126322002 @default.
• W4300690122 hasConcept C197934379 @default.
• W4300690122 hasConcept C2776153860 @default.
• W4300690122 hasConcept C2778062832 @default.
• W4300690122 hasConcept C2778715236 @default.
• W4300690122 hasConcept C2779034229 @default.
• W4300690122 hasConcept C2779541405 @default.
• W4300690122 hasConcept C2780035454 @default.

• next