Matches in SemOpenAlex for { <https://semopenalex.org/work/W4300690134> ?p ?o ?g. }
- W4300690134 endingPage "157" @default.
- W4300690134 startingPage "142" @default.
- W4300690134 abstract "The principle of trained immunity represents innate immune memory due to sustained, mainly epigenetic, changes triggered by endogenous or exogenous stimuli in bone marrow (BM) progenitors (central trained immunity) and their innate immune cell progeny, thereby triggering elevated responsiveness against secondary stimuli. BM progenitors can respond to microbial and sterile signals, thereby possibly acquiring trained immunity-mediated long-lasting alterations that may shape the fate and function of their progeny, for example, neutrophils. Neutrophils, the most abundant innate immune cell population, are produced in the BM from committed progenitor cells in a process designated granulopoiesis. Neutrophils are the first responders against infectious or inflammatory challenges and have versatile functions in immunity. Together with other innate immune cells, neutrophils are effectors of peripheral trained immunity. However, given the short lifetime of neutrophils, their ability to acquire immunological memory may lie in the central training of their BM progenitors resulting in generation of reprogrammed, that is, trained, neutrophils. Although trained immunity may have beneficial effects in infection or cancer, it may also mediate detrimental outcomes in chronic inflammation. Here, we review the emerging research area of trained immunity with a particular emphasis on the role of neutrophils and granulopoiesis." @default.
- W4300690134 created "2022-10-04" @default.
- W4300690134 creator A5021893175 @default.
- W4300690134 creator A5036030242 @default.
- W4300690134 creator A5084031628 @default.
- W4300690134 creator A5086672334 @default.
- W4300690134 date "2022-10-03" @default.
- W4300690134 modified "2023-10-14" @default.
- W4300690134 title "The role of neutrophils in trained immunity" @default.
- W4300690134 cites W1616668006 @default.
- W4300690134 cites W1767934134 @default.
- W4300690134 cites W1781424562 @default.
- W4300690134 cites W1784229545 @default.
- W4300690134 cites W1913879859 @default.
- W4300690134 cites W1944560965 @default.
- W4300690134 cites W1966900148 @default.
- W4300690134 cites W1970845955 @default.
- W4300690134 cites W1987591286 @default.
- W4300690134 cites W1991767888 @default.
- W4300690134 cites W1994063461 @default.
- W4300690134 cites W1994190235 @default.
- W4300690134 cites W1995247342 @default.
- W4300690134 cites W1998907198 @default.
- W4300690134 cites W2002072152 @default.
- W4300690134 cites W2004638361 @default.
- W4300690134 cites W2005757388 @default.
- W4300690134 cites W2010570889 @default.
- W4300690134 cites W2013301732 @default.
- W4300690134 cites W2018643167 @default.
- W4300690134 cites W2019676650 @default.
- W4300690134 cites W2033883349 @default.
- W4300690134 cites W2036484015 @default.
- W4300690134 cites W2038920846 @default.
- W4300690134 cites W2038955872 @default.
- W4300690134 cites W2041971745 @default.
- W4300690134 cites W2044984438 @default.
- W4300690134 cites W2046414943 @default.
- W4300690134 cites W2054241879 @default.
- W4300690134 cites W2058331779 @default.
- W4300690134 cites W2059287796 @default.
- W4300690134 cites W2059403792 @default.
- W4300690134 cites W2061339845 @default.
- W4300690134 cites W2062019575 @default.
- W4300690134 cites W2062147513 @default.
- W4300690134 cites W2067031028 @default.
- W4300690134 cites W2067401763 @default.
- W4300690134 cites W2067769931 @default.
- W4300690134 cites W2069039226 @default.
- W4300690134 cites W2070117107 @default.
- W4300690134 cites W2077173382 @default.
- W4300690134 cites W2077553363 @default.
- W4300690134 cites W2080709645 @default.
- W4300690134 cites W2087143957 @default.
- W4300690134 cites W2089077748 @default.
- W4300690134 cites W2091836761 @default.
- W4300690134 cites W2099172760 @default.
- W4300690134 cites W2101706701 @default.
- W4300690134 cites W2104312694 @default.
- W4300690134 cites W2108093856 @default.
- W4300690134 cites W2109205846 @default.
- W4300690134 cites W2110299641 @default.
- W4300690134 cites W2112671019 @default.
- W4300690134 cites W2114749317 @default.
- W4300690134 cites W2114870653 @default.
- W4300690134 cites W2116797415 @default.
- W4300690134 cites W2120298176 @default.
- W4300690134 cites W2125894404 @default.
- W4300690134 cites W2128337342 @default.
- W4300690134 cites W2134928825 @default.
- W4300690134 cites W2138694950 @default.
- W4300690134 cites W2140876277 @default.
- W4300690134 cites W2143437930 @default.
- W4300690134 cites W2145019007 @default.
- W4300690134 cites W2145899814 @default.
- W4300690134 cites W2149569216 @default.
- W4300690134 cites W2150594596 @default.
- W4300690134 cites W2150906421 @default.
- W4300690134 cites W2157673587 @default.
- W4300690134 cites W2158580948 @default.
- W4300690134 cites W2158667202 @default.
- W4300690134 cites W2159913536 @default.
- W4300690134 cites W2162738653 @default.
- W4300690134 cites W2162749628 @default.
- W4300690134 cites W2165947392 @default.
- W4300690134 cites W2167640933 @default.
- W4300690134 cites W2206690131 @default.
- W4300690134 cites W2336656712 @default.
- W4300690134 cites W2337701902 @default.
- W4300690134 cites W2343868815 @default.
- W4300690134 cites W2380561061 @default.
- W4300690134 cites W2401807508 @default.
- W4300690134 cites W2466101935 @default.
- W4300690134 cites W2498232546 @default.
- W4300690134 cites W2507799633 @default.
- W4300690134 cites W2529875271 @default.
- W4300690134 cites W2533310720 @default.
- W4300690134 cites W2556702335 @default.
- W4300690134 cites W2557169014 @default.