Matches in SemOpenAlex for { <https://semopenalex.org/work/W4300690189> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W4300690189 endingPage "1719" @default.
- W4300690189 startingPage "1713" @default.
- W4300690189 abstract "Accumulation of mutations in epitopes of cytolytic-T-lymphocytes immune response (CTL) in HIV-reservoir seems to be one of the reasons for shock-and-kill strategy failure. Ten non-controller patients on successful cART (TX) and seven elite controllers (EC) were included. HIV-Gag gene from purified resting memory CD4+ T-cells was sequenced by Next-Generation-Sequencing. HLA class-I alleles were typed to predict optimal HIV-Gag CTL epitopes. For each subject, the frequency of mutated epitopes in the HIV-Gag gene, the proportion of them considered as CTL-escape variants as well as their effect on antigen recognition by HLA were assessed. The proportion (%) of mutated HIV-Gag CTL epitopes in the reservoir was high and similar in EC and TX (86%[50–100] and 57%[48–82] respectively, p=0.315). Many of them were predicted to negatively impact antigen recognition. Moreover, the proportion of mutated epitopes considered to be CTL-escape variants was also similar in TX and EC (77%[49–92] vs. 50%[33–75] respectively, p=0.117). Thus, the most relevant finding of our study was the high and similar proportions of HIV-Gag CTL-escape mutations in the reservoir of both HIV-noncontroller patients with cART (TX) and patients with spontaneous HIV-control (EC). Our findings suggest that escape mutations of CTL-response may be another obstacle to eliminate the HIV reservoir and constitute a proof of concept that challenges HIV cure strategies focused on the reactivation of reservoirs. Due to the small sample size that could impact the robustness of the study, further studies with larger cohorts of elite controller patients are needed to confirm these results." @default.
- W4300690189 created "2022-10-04" @default.
- W4300690189 creator A5021477635 @default.
- W4300690189 creator A5036522089 @default.
- W4300690189 creator A5053312715 @default.
- W4300690189 creator A5056362459 @default.
- W4300690189 creator A5057107784 @default.
- W4300690189 creator A5081429565 @default.
- W4300690189 creator A5088233740 @default.
- W4300690189 date "2022-10-03" @default.
- W4300690189 modified "2023-10-16" @default.
- W4300690189 title "High frequency of CD8 escape mutations in elite controllers as new obstacle for HIV cure" @default.
- W4300690189 cites W1970640392 @default.
- W4300690189 cites W1971112771 @default.
- W4300690189 cites W1990651643 @default.
- W4300690189 cites W2001766969 @default.
- W4300690189 cites W2037524921 @default.
- W4300690189 cites W2051269276 @default.
- W4300690189 cites W2075106941 @default.
- W4300690189 cites W2081550246 @default.
- W4300690189 cites W2091071328 @default.
- W4300690189 cites W2091914094 @default.
- W4300690189 cites W2092368847 @default.
- W4300690189 cites W2101516953 @default.
- W4300690189 cites W2109552024 @default.
- W4300690189 cites W2109807253 @default.
- W4300690189 cites W2115580899 @default.
- W4300690189 cites W2141700353 @default.
- W4300690189 cites W2146329405 @default.
- W4300690189 cites W2166236842 @default.
- W4300690189 cites W2169182812 @default.
- W4300690189 cites W2735653597 @default.
- W4300690189 cites W2774292278 @default.
- W4300690189 cites W2891511548 @default.
- W4300690189 cites W3045243130 @default.
- W4300690189 doi "https://doi.org/10.1080/21505594.2022.2129353" @default.
- W4300690189 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36190143" @default.
- W4300690189 hasPublicationYear "2022" @default.
- W4300690189 type Work @default.
- W4300690189 citedByCount "0" @default.
- W4300690189 crossrefType "journal-article" @default.
- W4300690189 hasAuthorship W4300690189A5021477635 @default.
- W4300690189 hasAuthorship W4300690189A5036522089 @default.
- W4300690189 hasAuthorship W4300690189A5053312715 @default.
- W4300690189 hasAuthorship W4300690189A5056362459 @default.
- W4300690189 hasAuthorship W4300690189A5057107784 @default.
- W4300690189 hasAuthorship W4300690189A5081429565 @default.
- W4300690189 hasAuthorship W4300690189A5088233740 @default.
- W4300690189 hasBestOaLocation W43006901891 @default.
- W4300690189 hasConcept C147483822 @default.
- W4300690189 hasConcept C147969180 @default.
- W4300690189 hasConcept C159047783 @default.
- W4300690189 hasConcept C167672396 @default.
- W4300690189 hasConcept C188280979 @default.
- W4300690189 hasConcept C195616568 @default.
- W4300690189 hasConcept C203014093 @default.
- W4300690189 hasConcept C3013748606 @default.
- W4300690189 hasConcept C6881719 @default.
- W4300690189 hasConcept C86803240 @default.
- W4300690189 hasConcept C8891405 @default.
- W4300690189 hasConceptScore W4300690189C147483822 @default.
- W4300690189 hasConceptScore W4300690189C147969180 @default.
- W4300690189 hasConceptScore W4300690189C159047783 @default.
- W4300690189 hasConceptScore W4300690189C167672396 @default.
- W4300690189 hasConceptScore W4300690189C188280979 @default.
- W4300690189 hasConceptScore W4300690189C195616568 @default.
- W4300690189 hasConceptScore W4300690189C203014093 @default.
- W4300690189 hasConceptScore W4300690189C3013748606 @default.
- W4300690189 hasConceptScore W4300690189C6881719 @default.
- W4300690189 hasConceptScore W4300690189C86803240 @default.
- W4300690189 hasConceptScore W4300690189C8891405 @default.
- W4300690189 hasFunder F4320335322 @default.
- W4300690189 hasIssue "1" @default.
- W4300690189 hasLocation W43006901891 @default.
- W4300690189 hasLocation W43006901892 @default.
- W4300690189 hasLocation W43006901893 @default.
- W4300690189 hasOpenAccess W4300690189 @default.
- W4300690189 hasPrimaryLocation W43006901891 @default.
- W4300690189 hasRelatedWork W1498853706 @default.
- W4300690189 hasRelatedWork W1664174075 @default.
- W4300690189 hasRelatedWork W1992039355 @default.
- W4300690189 hasRelatedWork W1993666283 @default.
- W4300690189 hasRelatedWork W2052483994 @default.
- W4300690189 hasRelatedWork W2063316104 @default.
- W4300690189 hasRelatedWork W2075073205 @default.
- W4300690189 hasRelatedWork W2112110584 @default.
- W4300690189 hasRelatedWork W2155176036 @default.
- W4300690189 hasRelatedWork W2175051607 @default.
- W4300690189 hasVolume "13" @default.
- W4300690189 isParatext "false" @default.
- W4300690189 isRetracted "false" @default.
- W4300690189 workType "article" @default.