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- W4300690265 endingPage "e1010894" @default.
- W4300690265 startingPage "e1010894" @default.
- W4300690265 abstract "Streptococcus gallolyticus subspecies gallolyticus ( Sgg ) has a strong clinical association with colorectal cancer (CRC) and actively promotes the development of colon tumors. Previous work showed that this organism stimulates CRC cells proliferation and tumor growth. However, the molecular mechanisms underlying these activities are not well understood. Here, we found that Sgg upregulates the expression of several type of collagens in HT29 and HCT116 cells, with type VI collagen (ColVI) being the highest upregulated type. Knockdown of ColVI abolished the ability of Sgg to induce cell proliferation and reduced the adherence of Sgg to CRC cells. The extracellular matrix (ECM) is an important regulator of cell proliferation. Therefore, we further examined the role of decellularized matrix (dc-matrix), which is free of live bacteria or cells, in Sgg -induced cell proliferation. Dc-matrix prepared from Sgg -treated cells showed a significantly higher pro-proliferative activity than that from untreated cells or cells treated with control bacteria. On the other hand, dc-matrix from Sgg -treated ColVI knockdown cells showed no difference in the capacity to support cell proliferation compared to that from untreated ColVI knockdown cells, suggesting that the ECM by itself is a mediator of Sgg -induced cell proliferation. Furthermore, Sgg treatment of CRC cells but not ColVI knockdown CRC cells resulted in significantly larger tumors in vivo , suggesting that ColVI is important for Sgg to promote tumor growth in vivo . These results highlight a dynamic bidirectional interplay between Sgg and the ECM, where Sgg upregulates collagen expression. The Sgg -modified ECM in turn affects the ability of Sgg to adhere to host cells and more importantly, acts as a mediator for Sgg -induced CRC cell proliferation. Taken together, our results reveal a novel mechanism in which Sgg stimulates CRC proliferation through modulation of the ECM." @default.
- W4300690265 created "2022-10-04" @default.
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- W4300690265 date "2022-10-03" @default.
- W4300690265 modified "2023-10-18" @default.
- W4300690265 title "Modulation of the extracellular matrix by Streptococcus gallolyticus subsp. gallolyticus and importance in cell proliferation" @default.
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- W4300690265 doi "https://doi.org/10.1371/journal.ppat.1010894" @default.
- W4300690265 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36191045" @default.
- W4300690265 hasPublicationYear "2022" @default.
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