FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4300690475> ?p ?o ?g. }

• W4300690475 endingPage "e1010543" @default.
• W4300690475 startingPage "e1010543" @default.
• W4300690475 abstract "Short-term synaptic plasticity and modulations of the presynaptic vesicle release rate are key components of many working memory models. At the same time, an increasing number of studies suggests a potential role of astrocytes in modulating higher cognitive function such as WM through their influence on synaptic transmission. Which influence astrocytic signaling could have on the stability and duration of WM representations, however, is still unclear. Here, we introduce a slow, activity-dependent astrocytic regulation of the presynaptic release probability in a synaptic attractor model of WM. We compare and analyze simulations of a simple WM protocol in firing rate and spiking networks with and without astrocytic regulation, and underpin our observations with analyses of the phase space dynamics in the rate network. We find that the duration and stability of working memory representations are altered by astrocytic signaling and by noise. We show that astrocytic signaling modulates the mean duration of WM representations. Moreover, if the astrocytic regulation is strong, a slow presynaptic timescale introduces a 'window of vulnerability', during which WM representations are easily disruptable by noise before being stabilized. We identify two mechanisms through which noise from different sources in the network can either stabilize or destabilize WM representations. Our findings suggest that (i) astrocytic regulation can act as a crucial determinant for the duration of WM representations in synaptic attractor models of WM, and (ii) that astrocytic signaling could facilitate different mechanisms for volitional top-down control of WM representations and their duration." @default.
• W4300690475 created "2022-10-04" @default.
• W4300690475 creator A5030975818 @default.
• W4300690475 creator A5046659242 @default.
• W4300690475 creator A5084995338 @default.
• W4300690475 date "2022-10-03" @default.
• W4300690475 modified "2023-10-18" @default.
• W4300690475 title "Modulation of working memory duration by synaptic and astrocytic mechanisms" @default.
• W4300690475 cites W1485297825 @default.
• W4300690475 cites W1582051163 @default.
• W4300690475 cites W1635648989 @default.
• W4300690475 cites W1939596644 @default.
• W4300690475 cites W1975961509 @default.
• W4300690475 cites W1976804176 @default.
• W4300690475 cites W1977906889 @default.
• W4300690475 cites W2019862953 @default.
• W4300690475 cites W2028180629 @default.
• W4300690475 cites W2030216847 @default.
• W4300690475 cites W2036145275 @default.
• W4300690475 cites W2038769137 @default.
• W4300690475 cites W2040359323 @default.
• W4300690475 cites W2042681276 @default.
• W4300690475 cites W2044730840 @default.
• W4300690475 cites W2048105028 @default.
• W4300690475 cites W2048709976 @default.
• W4300690475 cites W2066701533 @default.
• W4300690475 cites W2070900790 @default.
• W4300690475 cites W2072652550 @default.
• W4300690475 cites W2076044406 @default.
• W4300690475 cites W2076177169 @default.
• W4300690475 cites W2076919983 @default.
• W4300690475 cites W2085268499 @default.
• W4300690475 cites W2092811171 @default.
• W4300690475 cites W2094205031 @default.
• W4300690475 cites W2112927743 @default.
• W4300690475 cites W2114841249 @default.
• W4300690475 cites W2121579477 @default.
• W4300690475 cites W2123609069 @default.
• W4300690475 cites W2135890484 @default.
• W4300690475 cites W2142717029 @default.
• W4300690475 cites W2148654448 @default.
• W4300690475 cites W2168462263 @default.
• W4300690475 cites W2170437301 @default.
• W4300690475 cites W2170547012 @default.
• W4300690475 cites W2223729911 @default.
• W4300690475 cites W2297363866 @default.
• W4300690475 cites W2300385599 @default.
• W4300690475 cites W2335468953 @default.
• W4300690475 cites W2337880134 @default.
• W4300690475 cites W2553604012 @default.
• W4300690475 cites W2563613099 @default.
• W4300690475 cites W2568841898 @default.
• W4300690475 cites W2581476630 @default.
• W4300690475 cites W2586089363 @default.
• W4300690475 cites W2594475619 @default.
• W4300690475 cites W2611485120 @default.
• W4300690475 cites W2765155499 @default.
• W4300690475 cites W2784079369 @default.
• W4300690475 cites W2801908796 @default.
• W4300690475 cites W2883380036 @default.
• W4300690475 cites W2885859974 @default.
• W4300690475 cites W2898524098 @default.
• W4300690475 cites W2901093770 @default.
• W4300690475 cites W2911011469 @default.
• W4300690475 cites W2924003502 @default.
• W4300690475 cites W2945232580 @default.
• W4300690475 cites W2950043157 @default.
• W4300690475 cites W2950800702 @default.
• W4300690475 cites W2952185808 @default.
• W4300690475 cites W2955753775 @default.
• W4300690475 cites W3028832426 @default.
• W4300690475 cites W3036274064 @default.
• W4300690475 cites W3102960856 @default.
• W4300690475 cites W3149655929 @default.
• W4300690475 cites W3203630346 @default.
• W4300690475 cites W4242832026 @default.
• W4300690475 doi "https://doi.org/10.1371/journal.pcbi.1010543" @default.
• W4300690475 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36191056" @default.
• W4300690475 hasPublicationYear "2022" @default.
• W4300690475 type Work @default.
• W4300690475 citedByCount "6" @default.
• W4300690475 countsByYear W43006904752022 @default.
• W4300690475 countsByYear W43006904752023 @default.
• W4300690475 crossrefType "journal-article" @default.
• W4300690475 hasAuthorship W4300690475A5030975818 @default.
• W4300690475 hasAuthorship W4300690475A5046659242 @default.
• W4300690475 hasAuthorship W4300690475A5084995338 @default.
• W4300690475 hasBestOaLocation W43006904751 @default.
• W4300690475 hasConcept C112758219 @default.
• W4300690475 hasConcept C121332964 @default.
• W4300690475 hasConcept C134306372 @default.
• W4300690475 hasConcept C15744967 @default.
• W4300690475 hasConcept C164380108 @default.
• W4300690475 hasConcept C169760540 @default.
• W4300690475 hasConcept C169900460 @default.
• W4300690475 hasConcept C170493617 @default.
• W4300690475 hasConcept C200170125 @default.
• W4300690475 hasConcept C21963081 @default.

• next