Matches in SemOpenAlex for { <https://semopenalex.org/work/W4300690601> ?p ?o ?g. }
- W4300690601 abstract "Num1 is a multifunctional protein that both tethers mitochondria to the plasma membrane and anchors dynein to the cell cortex during nuclear inheritance. Previous work has examined the impact loss of Num1-based mitochondrial tethering has on dynein function in Saccharomyces cerevisiae; here, we elucidate its impact on mitochondrial function. We find that like mitochondria, Num1 is regulated by changes in metabolic state, with the protein levels and cortical distribution of Num1 differing between fermentative and respiratory growth conditions. In cells lacking Num1, we observe a reproducible respiratory growth defect, suggesting a role for Num1 in not only maintaining mitochondrial morphology, but also function. A structure-function approach revealed that, unexpectedly, Num1-mediated cortical dynein anchoring is important for normal growth under respiratory conditions. The severe respiratory growth defect in Δnum1 cells is not specifically due to the canonical functions of dynein in nuclear migration but is dependent on the presence of dynein, as deletion of DYN1 in Δnum1 cells partially rescues respiratory growth. We hypothesize that misregulated dynein present in cells that lack Num1 negatively impacts mitochondrial function resulting in defects in respiratory growth." @default.
- W4300690601 created "2022-10-04" @default.
- W4300690601 creator A5010236361 @default.
- W4300690601 creator A5017905827 @default.
- W4300690601 creator A5024046200 @default.
- W4300690601 creator A5034960334 @default.
- W4300690601 creator A5038842065 @default.
- W4300690601 creator A5075516950 @default.
- W4300690601 creator A5083054749 @default.
- W4300690601 creator A5085716256 @default.
- W4300690601 date "2022-10-31" @default.
- W4300690601 modified "2023-10-15" @default.
- W4300690601 title "Loss of Num1-mediated cortical dynein anchoring negatively impacts respiratory growth" @default.
- W4300690601 cites W1493752155 @default.
- W4300690601 cites W1556836946 @default.
- W4300690601 cites W1836777851 @default.
- W4300690601 cites W1966072209 @default.
- W4300690601 cites W1973275541 @default.
- W4300690601 cites W1973889018 @default.
- W4300690601 cites W1974276027 @default.
- W4300690601 cites W1975425948 @default.
- W4300690601 cites W1976074435 @default.
- W4300690601 cites W1979328799 @default.
- W4300690601 cites W1982176321 @default.
- W4300690601 cites W1984816905 @default.
- W4300690601 cites W1990341894 @default.
- W4300690601 cites W1991221769 @default.
- W4300690601 cites W1991931009 @default.
- W4300690601 cites W1996888932 @default.
- W4300690601 cites W1997527771 @default.
- W4300690601 cites W1997859335 @default.
- W4300690601 cites W1999768397 @default.
- W4300690601 cites W2004926885 @default.
- W4300690601 cites W2007237942 @default.
- W4300690601 cites W2033361228 @default.
- W4300690601 cites W2039813177 @default.
- W4300690601 cites W2044668046 @default.
- W4300690601 cites W2046561940 @default.
- W4300690601 cites W2048522870 @default.
- W4300690601 cites W2054836163 @default.
- W4300690601 cites W2066029883 @default.
- W4300690601 cites W2068119233 @default.
- W4300690601 cites W2072383593 @default.
- W4300690601 cites W2074865624 @default.
- W4300690601 cites W2078146767 @default.
- W4300690601 cites W2083704406 @default.
- W4300690601 cites W2087904752 @default.
- W4300690601 cites W2099287530 @default.
- W4300690601 cites W2101427530 @default.
- W4300690601 cites W2105769353 @default.
- W4300690601 cites W2112213210 @default.
- W4300690601 cites W2115586443 @default.
- W4300690601 cites W2117962007 @default.
- W4300690601 cites W2122213881 @default.
- W4300690601 cites W2122401596 @default.
- W4300690601 cites W2133664013 @default.
- W4300690601 cites W2134724543 @default.
- W4300690601 cites W2135588013 @default.
- W4300690601 cites W2138760198 @default.
- W4300690601 cites W2140008017 @default.
- W4300690601 cites W2146750095 @default.
- W4300690601 cites W2146831574 @default.
- W4300690601 cites W2149151220 @default.
- W4300690601 cites W2149507674 @default.
- W4300690601 cites W2149773499 @default.
- W4300690601 cites W2151466553 @default.
- W4300690601 cites W2152969835 @default.
- W4300690601 cites W2154164675 @default.
- W4300690601 cites W2160013167 @default.
- W4300690601 cites W2164702837 @default.
- W4300690601 cites W2165843409 @default.
- W4300690601 cites W2169610187 @default.
- W4300690601 cites W2299595268 @default.
- W4300690601 cites W2412024369 @default.
- W4300690601 cites W2552202209 @default.
- W4300690601 cites W2552607372 @default.
- W4300690601 cites W2620362933 @default.
- W4300690601 cites W2697643565 @default.
- W4300690601 cites W2746274125 @default.
- W4300690601 cites W2805576450 @default.
- W4300690601 cites W2838398497 @default.
- W4300690601 cites W2885905343 @default.
- W4300690601 cites W2908680302 @default.
- W4300690601 cites W2924515523 @default.
- W4300690601 cites W2928276296 @default.
- W4300690601 cites W2987979134 @default.
- W4300690601 cites W3001251642 @default.
- W4300690601 cites W3003440392 @default.
- W4300690601 cites W3007815320 @default.
- W4300690601 cites W3012823307 @default.
- W4300690601 cites W3043252205 @default.
- W4300690601 cites W3085780609 @default.
- W4300690601 cites W3104572769 @default.
- W4300690601 cites W3139719395 @default.
- W4300690601 cites W4206760140 @default.
- W4300690601 cites W4226272216 @default.
- W4300690601 cites W4246573955 @default.
- W4300690601 doi "https://doi.org/10.1242/jcs.259980" @default.
- W4300690601 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36185004" @default.
- W4300690601 hasPublicationYear "2022" @default.