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- W4300690766 abstract "We report a new positively charged azidoamino acid for strain-promoted azide–alkyne cycloaddition (SPAAC) applications that overcomes possible solubility limitations of commonly used azidolysine, especially in systems with numerous ligation sites. The residue is easily synthesized, is compatible with Fmoc-based solid-phase peptide synthesis employing a range of coupling conditions, and offers efficient second-order rate constants in SPAAC ligations employing DBCO (0.34 M–1 s–1) and BCN (0.28 M–1 s–1)." @default.
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- W4300690766 date "2022-10-03" @default.
- W4300690766 modified "2023-09-24" @default.
- W4300690766 title "Hydrophilic Azide-Containing Amino Acid to Enhance the Solubility of Peptides for SPAAC Reactions" @default.
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- W4300690766 doi "https://doi.org/10.1021/acs.orglett.2c02906" @default.
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