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• W4300690810 abstract "Breast cancer is the most devastating disease for women. There is a great demand for new sources to treat this disease. Medicinal plants are an indispensable source of bioactive compounds with wide range of pharmacological activities. In-vitro cytotoxic activity of Otostegia fruticosa methanolic extract against human breast cancer was studied using MCF-7 cell line. The extract showed mildly potent activity (IC50 = 51 ± 9.836 µg/mL) in comparison to the standard anticancer doxorubicin (IC50 = 7.467 ± 1.05 µg/mL). Potential compounds responsible for activity have been identified using Molecular Operating Environment (MOE) module on the major compounds detected by HPLC-MS/MS technique against estrogen alpha receptor (ERα+: PDB ID 2JF9). 3,5-di-O-dicaffeoylquinic acid, hyperoside and rutin showed similar binding and antagonistic interaction with the estrogen alpha receptor as tamoxifen in several poses. The retrieved results confirm that we can add this plant to a powerful arsenal that combats this insidious disease." @default.
• W4300690810 created "2022-10-04" @default.
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• W4300690810 date "2022-10-03" @default.
• W4300690810 modified "2023-10-18" @default.
• W4300690810 title "A new firewall in the fight against breast cancer: <i>in-vitro</i> and <i>in-silico</i> studies correlating chemistry to apoptotic activity of <i>Otostegia fruticosa</i>" @default.
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• W4300690810 doi "https://doi.org/10.1080/14786419.2022.2130306" @default.
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