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- W4300724215 abstract "It is well known that the general transcription factors (GTF) specifically recognize correct TATA boxes, distinguishing them from many others. Employing the principles of determinacy analysis (mathematical theory of rules) we analyzed a fragment of human chromosome 1 DNA sequence and identified specific genetic markers (IG-markers = Irreducible Genetic markers) in the nearest proximity to TATAAA motifs. The IG-markers enable determining the exact location of any TATAAA motif within the investigated DNA fragment. Based on our data we hypothesize that the GTF recognize the {guillemotleft}true{guillemotright} transcriptional start TATA box by means of IG-markers. The math method described here is universal and can be used to find IG-markers that will provide, like a global navigation satellite system, for the specific location of any distinct sequence motif within larger DNA sequence content." @default.
- W4300724215 created "2022-10-04" @default.
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- W4300724215 date "2012-03-29" @default.
- W4300724215 modified "2023-09-27" @default.
- W4300724215 title "Phenomenon of irreducible genetic markers for TATAAA motifs in human chromosome 1" @default.
- W4300724215 doi "https://doi.org/10.48550/arxiv.1203.6465" @default.
- W4300724215 hasPublicationYear "2012" @default.
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