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- W4300748622 abstract "The study of neural induction in Xenopus can be approached from two broad perspectives. One can study the competence of the ectoderm to respond to neural induction signals and any potential prepattern within the ectoderm. The second area of study involves the neural induction signals, in terms of the chemical nature of the signals, their sources, and their method of delivery. The neural competence of ectoderm has been studied by either grafting the ectoderm into areas which normally form neural tissue or by grafting tissues which normally induce neural structures onto the ectoderm to be tested. In general, it appears that ectoderm loses neural competence by midgastrula. However, there is some experimental evidence from various amphibian studies that the loss of neural competence in ectoderm does not occur simultaneously throughout all regions. It is not yet known if this phenomenon is also true in Xenopus. There appear to be several signaling events involved in the process of neural induction. Molecular probes have made it possible to study early steps in the neural induction and patterning processes which were not possible to study using only the development of neural morphology as a marker for neural induction. Antibodies directed against early epidermal versus neural epithelium indicate that the dorsal animal blastomeres are biased toward a neural pathway during early cleavage. Another signaling event occurs at early gastrula and the resulting dorsal ectoderm now responds more readily to some neural induction events than does the ventral ectoderm. The source of the early gastrula signals has been studied by a variety of methods, including exogastrula embryos, Keller sandwiches, and grafting a blastopore lip to the edge of competent ectoderm. The blastopore lip can send signals through the plane of the ectoderm capable of inducing competent ectoderm to become neural tissue. There are several issues relative to the process of neural induction which are not yet resolved. The major issue involves the mechanism of establishing pattern within the neural plate. Ectoderm appears to lose neural competence prior to the time when involuted dorsal mesoderm comes to underlie the anterior neural plate region. Several investigators have shown that information for expression of spatially restricted neural-specific molecules can travel through the ectoderm, independent of underlying dorsal mesoderm.(ABSTRACT TRUNCATED AT 400 WORDS)" @default.
- W4300748622 created "2022-10-04" @default.
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- W4300748622 date "1991-01-01" @default.
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- W4300748622 title "Neural induction." @default.
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