Matches in SemOpenAlex for { <https://semopenalex.org/work/W4300772259> ?p ?o ?g. }
- W4300772259 endingPage "101003" @default.
- W4300772259 startingPage "101003" @default.
- W4300772259 abstract "Although rare in children, arterial ischemic stroke (AIS) is associated with increased mortality and neurological morbidity. The incidence of AIS after the neonatal period is approximately 1-2/100,000/year, with an estimated mortality of 3-7%. A significant proportion of children surviving AIS experience life-long neurological deficits including hemiparesis, epilepsy, and cognitive delays. The low incidence of childhood AIS coupled with atypical clinical-presentation and lack of awareness contribute to delay in diagnosis and consequently, the early initiation of treatment. While randomized-clinical trials have demonstrated the efficacy and safety of reperfusion therapies including thrombolysis and endovascular thrombectomy in appropriately-selected adult patients, similar data for children are unavailable. Consequently, clinical decisions surrounding reperfusion therapy in childhood AIS are either extrapolated from adult data or based on local experience. The etiology of childhood AIS is multifactorial, often occurring in the setting of both acquired and congenital risk-factors including thrombophilia. While multiple studies have investigated the association of thrombophilia with incident childhood AIS, its impact on stroke recurrence and therefore duration and intensity of antithrombotic therapy is less clear. Despite these limitations, a significant progress has been made over the last decade in the management of childhood AIS. This progress can be attributed to international consortiums, and in selected cohorts to federally-funded clinical trials. In this narrative review, the authors have systematically appraised the literature and summarize the hemostatic and thrombotic considerations in the diagnosis and management of childhood AIS focusing on the evidence supporting reperfusion therapies, relevance of thrombophilia testing, and duration and drug choices for secondary-prophylaxis." @default.
- W4300772259 created "2022-10-04" @default.
- W4300772259 creator A5011457283 @default.
- W4300772259 creator A5017848480 @default.
- W4300772259 creator A5021997989 @default.
- W4300772259 creator A5034189122 @default.
- W4300772259 creator A5044775562 @default.
- W4300772259 creator A5066197445 @default.
- W4300772259 creator A5081252360 @default.
- W4300772259 creator A5090111395 @default.
- W4300772259 date "2022-10-01" @default.
- W4300772259 modified "2023-09-29" @default.
- W4300772259 title "Hemostatic and Thrombotic Considerations in the Diagnosis and Management of Childhood Arterial Ischemic Stroke: A Narrative Review" @default.
- W4300772259 cites W104552217 @default.
- W4300772259 cites W1498265361 @default.
- W4300772259 cites W1785297096 @default.
- W4300772259 cites W1893368076 @default.
- W4300772259 cites W1948695832 @default.
- W4300772259 cites W1982275986 @default.
- W4300772259 cites W1985218275 @default.
- W4300772259 cites W1985664799 @default.
- W4300772259 cites W1999482579 @default.
- W4300772259 cites W2005038503 @default.
- W4300772259 cites W2006269474 @default.
- W4300772259 cites W2007027050 @default.
- W4300772259 cites W2008330412 @default.
- W4300772259 cites W2009340203 @default.
- W4300772259 cites W2016998239 @default.
- W4300772259 cites W2017990016 @default.
- W4300772259 cites W2022031418 @default.
- W4300772259 cites W2023998195 @default.
- W4300772259 cites W2026458612 @default.
- W4300772259 cites W2040998137 @default.
- W4300772259 cites W2041169286 @default.
- W4300772259 cites W2042232724 @default.
- W4300772259 cites W2061854453 @default.
- W4300772259 cites W2073078878 @default.
- W4300772259 cites W2089848042 @default.
- W4300772259 cites W2092131208 @default.
- W4300772259 cites W2092259770 @default.
- W4300772259 cites W2093141344 @default.
- W4300772259 cites W2093902855 @default.
- W4300772259 cites W2097487666 @default.
- W4300772259 cites W2098264690 @default.
- W4300772259 cites W2103583969 @default.
- W4300772259 cites W2104790415 @default.
- W4300772259 cites W2106459062 @default.
- W4300772259 cites W2107065159 @default.
- W4300772259 cites W2110814699 @default.
- W4300772259 cites W2112879444 @default.
- W4300772259 cites W2116549926 @default.
- W4300772259 cites W2129854180 @default.
- W4300772259 cites W2131192729 @default.
- W4300772259 cites W2134148711 @default.
- W4300772259 cites W2134196875 @default.
- W4300772259 cites W2137252836 @default.
- W4300772259 cites W2140261980 @default.
- W4300772259 cites W2147828535 @default.
- W4300772259 cites W2166984312 @default.
- W4300772259 cites W2178190585 @default.
- W4300772259 cites W2218400246 @default.
- W4300772259 cites W2277258071 @default.
- W4300772259 cites W2292308933 @default.
- W4300772259 cites W2318560766 @default.
- W4300772259 cites W2428912743 @default.
- W4300772259 cites W2438755095 @default.
- W4300772259 cites W2581487214 @default.
- W4300772259 cites W2592177823 @default.
- W4300772259 cites W2624209246 @default.
- W4300772259 cites W2689050597 @default.
- W4300772259 cites W2751478501 @default.
- W4300772259 cites W2769601183 @default.
- W4300772259 cites W2909316539 @default.
- W4300772259 cites W2911497402 @default.
- W4300772259 cites W2912229616 @default.
- W4300772259 cites W2915008194 @default.
- W4300772259 cites W2921756627 @default.
- W4300772259 cites W2946085501 @default.
- W4300772259 cites W2968342331 @default.
- W4300772259 cites W2968554553 @default.
- W4300772259 cites W2969562042 @default.
- W4300772259 cites W2979810753 @default.
- W4300772259 cites W2995106932 @default.
- W4300772259 cites W3016914388 @default.
- W4300772259 cites W3023564401 @default.
- W4300772259 cites W3037731101 @default.
- W4300772259 cites W3085021208 @default.
- W4300772259 cites W3110676294 @default.
- W4300772259 cites W3115434937 @default.
- W4300772259 cites W3132267494 @default.
- W4300772259 cites W3138939949 @default.
- W4300772259 cites W3151621701 @default.
- W4300772259 cites W3157665740 @default.
- W4300772259 cites W3175628064 @default.
- W4300772259 cites W3183145959 @default.
- W4300772259 cites W3193240853 @default.
- W4300772259 cites W3201571219 @default.
- W4300772259 cites W4225843829 @default.